CATH Classification

Domain Context

CATH Clusters

Superfamily Transferase(Phosphotransferase) domain 1
Functional Family Protein kinase C iota

Enzyme Information
Protein kinase C.
based on mapping to UniProt P41743
ATP + a protein = ADP + a phosphoprotein.
-!- A family of serine- and threonine-specific protein kinases that depend on lipids for activity. -!- They can be activated by calcium but have a requirement for the second messenger diacylglycerol. -!- Members of this group of enzymes phosphorylate a wide variety of protein targets and are known to be involved in diverse cell- signaling pathways. -!- Members of the protein kinase C family also serve as major receptors for phorbol esters, a class of tumor promoters. -!- Formerly EC

UniProtKB Entries (1)

Homo sapiens
Protein kinase C iota type

PDB Structure

External Links
Organism Spodoptera
Primary Citation
Crystal Structure of the Catalytic Domain of Human Atypical Protein Kinase C-iota Reveals Interaction Mode of Phosphorylation Site in Turn Motif
Messerschmidt, A., Macieira, S., Velarde, M., Baedeker, M., Benda, C., Jestel, A., Brandstetter, H., Neuefeind, T., Blaesse, M.