CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
1 | Mainly Alpha |
|
1.10 | Orthogonal Bundle |
|
1.10.620 | Ribonucleotide Reductase, subunit A |
|
1.10.620.20 | Ribonucleotide Reductase, subunit A |
Domain Context
CATH Clusters
| Superfamily | Ribonucleotide Reductase, subunit A |
| Functional Family | Acyl-[acyl-carrier protein] desaturase |
Enzyme Information
| 1.14.19.- |
With oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water.
based on mapping to UniProt P9WNZ5
|
| 1.14.19.2 |
Stearoyl-[acyl-carrier-protein] 9-desaturase.
based on mapping to UniProt P9WNZ5
Stearoyl-[acyl-carrier protein] + 2 reduced ferredoxin [iron-sulfur] cluster + O(2) + 2 H(+) = oleoyl-[acyl-carrier protein] + 2 oxidized ferredoxin [iron-sulfur] cluster + 2 H(2)O.
-!- The enzyme is found in the lumen of plastids, where de novo biosynthesis of fatty acids occurs, and acts on freshly synthesized saturated fatty acids that are still linked to acyl-carrier protein. -!- The enzyme determines the position of the double bond by its distance from the carboxylic acid end of the fatty acid. -!- It also acts on palmitoyl-[acyl-carrier-protein]. -!- Formerly EC 1.14.99.6.
|
UniProtKB Entries (1)
| P9WNZ5 |
DESA2_MYCTU
Mycobacterium tuberculosis H37Rv
Putative acyl-[acyl-carrier-protein] desaturase DesA2
|
PDB Structure
| PDB | 1ZA0 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
X-ray structure of putative acyl-ACP desaturase DesA2 from Mycobacterium tuberculosis H37Rv.
Protein Sci.
|
