CATH Classification
Domain Context
CATH Clusters
| Superfamily | N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2 |
| Functional Family | Ketol-acid reductoisomerase family protein |
Enzyme Information
| 1.1.1.86 |
Ketol-acid reductoisomerase (NADP(+)).
based on mapping to UniProt Q01292
(1) (2R)-2,3-dihydroxy-3-methylbutanoate + NADP(+) = (2S)-2-hydroxy-2- methyl-3-oxobutanoate + NADPH. (2) (2R,3R)-2,3-dihydroxy-3-methylpentanoate + NADP(+) = (S)-2-hydroxy-2- ethyl-3-oxobutanoate + NADPH.
-!- The enzyme, found in many bacteria and archaea, is specific for NADPH (cf. EC 1.1.1.382 and EC 1.1.1.383). -!- Formerly EC 1.1.1.89.
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UniProtKB Entries (1)
| Q01292 |
ILV5_SPIOL
Spinacia oleracea
Ketol-acid reductoisomerase, chloroplastic
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PDB Structure
| PDB | 1YVE |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
The crystal structure of plant acetohydroxy acid isomeroreductase complexed with NADPH, two magnesium ions and a herbicidal transition state analog determined at 1.65 A resolution.
EMBO J.
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