CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
1 | Mainly Alpha |
|
1.20 | Up-down Bundle |
|
1.20.5 | Single alpha-helices involved in coiled-coils or other helix-helix interfaces |
|
1.20.5.540 | Single helix bin |
Domain Context
CATH Clusters
| Superfamily | Single helix bin |
| Functional Family | Mitochondrial succinate dehydrogenase cytochrome b560 subunit |
Enzyme Information
| 1.3.5.1 |
Succinate dehydrogenase (quinone).
based on mapping to UniProt D0VWW3
Succinate + a quinone = fumarate + a quinol.
-!- The enzyme is found in the inner mitochondrial membrane in eukaryotes and the plasma membrane of many aerobic or facultative bacteria. -!- It catalyzes succinate oxidation in the citric acid cycle and transfers the electrons to quinones in the membrane, thus constituting a part of the aerobic respiratory chain (known as complex II). -!- In vivo the enzyme uses the quinone found in the organism - eukaryotic enzymes utilize ubiquinone, bacterial enzymes utilize ubiquinone or menaquinone, and archaebacterial enzymes from the Sulfolobus genus use caldariellaquinone. -!- Cf. EC 1.3.5.4.
|
UniProtKB Entries (1)
| Q5ZIS0 |
DHSD_CHICK
Gallus gallus
Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial
|
PDB Structure
| PDB | 1YQ4 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
3-Nitropropionic Acid Is a Suicide Inhibitor of Mitochondrial Respiration That, upon Oxidation by Complex II, Forms a Covalent Adduct with a Catalytic Base Arginine in the Active Site of the Enzyme
J.Biol.Chem.
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