CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.30 | 2-Layer Sandwich |
|
3.30.1600 | SIR2/SIRT2 'Small Domain' |
|
3.30.1600.10 | SIR2/SIRT2 'Small Domain' |
Domain Context
CATH Clusters
| Superfamily | SIR2/SIRT2 'Small Domain' |
| Functional Family | NAD-dependent protein deacetylase |
Enzyme Information
| 3.5.1.- |
In linear amides.
based on mapping to UniProt Q9WYW0
|
UniProtKB Entries (2)
| Q9WYW0 |
NPD_THEMA
Thermotoga maritima MSB8
NAD-dependent protein deacetylase
|
| P04637 |
P53_HUMAN
Homo sapiens
Cellular tumor antigen p53
|
PDB Structure
| PDB | 1YC5 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
Mechanism of sirtuin inhibition by nicotinamide: altering the NAD(+) cosubstrate specificity of a Sir2 enzyme.
Mol.Cell
|