CATH Classification

Domain Context

CATH Clusters

Superfamily Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain
Functional Family Double-stranded RNA-specific adenosine deaminase

Enzyme Information

3.5.4.37
Double-stranded RNA adenine deaminase.
based on mapping to UniProt P55265
Adenine in double-stranded RNA + H(2)O = hypoxanthine in double-stranded RNA + NH(3).
-!- This eukaryotic enzyme is involved in RNA editing. -!- It destabilizes double-stranded RNA through conversion of adenosine to inosine. -!- Inositol hexakisphosphate is required for activity.

UniProtKB Entries (1)

P55265
DSRAD_HUMAN
Homo sapiens
Double-stranded RNA-specific adenosine deaminase

PDB Structure

PDB 1XMK
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
The Crystal Structure of the Z[beta] Domain of the RNA-editing Enzyme ADAR1 Reveals Distinct Conserved Surfaces Among Z-domains.
Athanasiadis, A., Placido, D., Maas, S., Brown II, B.A., Lowenhaupt, K., Rich, A.
J.Mol.Biol.