CATH Classification

Domain Context

CATH Clusters

Superfamily EF-hand
Functional Family

Enzyme Information

2.7.11.19
Phosphorylase kinase.
based on mapping to UniProt P62158
2 ATP + phosphorylase b = 2 ADP + phosphorylase a.
-!- Requires calmodulin for activity. -!- The enzyme phosphorylates a specific serine residue in each of the subunits of the dimeric phosphorylase b. -!- For muscle phosphorylase but not liver phosphorylase, this is accompanied by a further dimerization to form a tetrameric phosphorylase. -!- The enzyme couples muscle contraction with energy production via glycogenolysis--glycolysis by catalyzing the Ca(2+)-dependent phosphorylation and activation of glycogen phosphorylase b. -!- The gamma subunit of the tetrameric alpha-beta-gamma-delta enzyme is the catalytic subunit. -!- Formerly EC 2.7.1.38.

UniProtKB Entries (1)

P40136
CYAA_BACAN
Bacillus anthracis
Calmodulin-sensitive adenylate cyclase

PDB Structure

PDB 1XFX
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Calcium-independent calmodulin binding and two-metal-ion catalytic mechanism of anthrax edema factor.
Shen, Y., Zhukovskaya, N.L., Guo, Q., Florian, J., Tang, W.J.
EMBO J.