CATH Classification

Domain Context

CATH Clusters

Superfamily Spore Coat Polysaccharide Biosynthesis Protein SpsA; Chain A
Functional Family 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, chloroplastic

Enzyme Information

2.7.7.60
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase.
based on mapping to UniProt P69834
CTP + 2-C-methyl-D-erythritol 4-phosphate = diphosphate + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol.
-!- ATP or UTP can replace CTP, but both are less effective. -!- GTP and TTP are not substrates. -!- Forms part of an alternative nonmevalonate pathway for terpenoid biosynthesis.

UniProtKB Entries (1)

P69834
ISPD_ARATH
Arabidopsis thaliana
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, chloroplastic

PDB Structure

PDB 1W77
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
The Crystal Structure of a Plant 2C-Methyl-D-Erythritol 4-Phosphate Cytidylyltransferase Exhibits a Distinct Quaternary Structure Compared to Bacterial Homologues and a Possible Role in Feedback Regulation for Cytidine Monophosphate.
Gabrielsen, M., Kaiser, J., Rohdich, F., Eisenreich, W., Laupitz, R., Bacher, A., Bond, C.S., Hunter, W.N.
FEBS J.