CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.30 | 2-Layer Sandwich |
|
3.30.460 | Beta Polymerase; domain 2 |
|
3.30.460.10 | Beta Polymerase, domain 2 |
Domain Context
CATH Clusters
| Superfamily | Beta Polymerase, domain 2 |
| Functional Family | Bifunctional (P)ppGpp synthase/hydrolase RelA |
Enzyme Information
| 2.7.6.5 |
GTP diphosphokinase.
based on mapping to UniProt Q54089
ATP + GTP = AMP + guanosine 3'-diphosphate 5'-triphosphate.
-!- GDP can also act as acceptor.
|
| 3.1.7.2 |
Guanosine-3',5'-bis(diphosphate) 3'-diphosphatase.
based on mapping to UniProt Q54089
Guanosine 3',5'-bis(diphosphate) + H(2)O = guanosine 5'-diphosphate + diphosphate.
|
UniProtKB Entries (1)
| Q54089 |
RELA_STREQ
Streptococcus dysgalactiae subsp. equisimilis
Bifunctional (p)ppGpp synthase/hydrolase RelA
|
PDB Structure
| PDB | 1VJ7 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
Conformational antagonism between opposing active sites in a bifunctional RelA/SpoT homolog modulates (p)ppGpp metabolism during the stringent response.
Cell(Cambridge,Mass.)
|