CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.30 | 2-Layer Sandwich |
|
3.30.66 | Viral Topoisomerase I |
|
3.30.66.10 | DNA topoisomerase I domain |
Domain Context
CATH Clusters
| Superfamily | DNA topoisomerase I domain |
| Functional Family | DNA topoisomerase 1 |
Enzyme Information
| 5.99.1.2 |
DNA topoisomerase.
based on mapping to UniProt P68698
ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.
-!- Brings about the conversion of one topological isomer of DNA into another, e.g. the relaxation of superhelical turns in DNA, the interconversion of simple and knotted rings of single-stranded DNA, and the intertwisting of single-stranded rings of complementary sequences (cf. EC 5.99.1.3).
|
UniProtKB Entries (1)
| P68698 |
TOP1_VACCW
Vaccinia virus WR
DNA topoisomerase 1B
|
PDB Structure
| PDB | 1VCC |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
Crystal structure of the amino-terminal fragment of vaccinia virus DNA topoisomerase I at 1.6 A resolution.
Structure
|