CATH Classification

Domain Context

CATH Clusters

Superfamily 3.40.50.1580
Functional Family Purine nucleoside phosphorylase 1

Enzyme Information

2.4.2.1
Purine-nucleoside phosphorylase.
based on mapping to UniProt P00491
(1) Purine nucleoside + phosphate = purine + alpha-D-ribose 1-phosphate. (2) Purine deoxynucleoside + phosphate = purine + 2'-deoxy-alpha-D-ribose 1-phosphate.
-!- Specificity not completely determined. -!- Can also catalyze ribosyltransferase reactions of the type catalyzed by EC 2.4.2.5.

UniProtKB Entries (1)

P00491
PNPH_HUMAN
Homo sapiens
Purine nucleoside phosphorylase

PDB Structure

PDB 1V2H
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Crystal structure of human PNP complexed with guanine.
de Azevedo Jr., W.F., Canduri, F., dos Santos, D.M., Pereira, J.H., Bertacine Dias, M.V., Silva, R.G., Mendes, M.A., Basso, L.A., Palma, M.S., Santos, D.S.
Biochem.Biophys.Res.Commun.