1 keywords

CATH Domain 1uouA01

CATH Classification

Level CATH Code Description
Class 1 Mainly Alpha
Architecture 1.20 Up-down Bundle
Topology 1.20.970 Transferase, Pyrimidine Nucleoside Phosphorylase; Chain A, domain 3
Homologous Superfamily 1.20.970.10 Transferase, Pyrimidine Nucleoside Phosphorylase; Chain C

Domain Context

CATH Clusters

Superfamily Transferase, Pyrimidine Nucleoside Phosphorylase; Chain C
Functional Family Pyrimidine-nucleoside (Thymidine) phosphorylase

Enzyme Information

2.4.2.4
Thymidine phosphorylase.
based on mapping to UniProt P19971
Thymidine + phosphate = thymine + 2-deoxy-alpha-D-ribose 1-phosphate.
-!- In some tissues also catalyzes deoxyribosyltransferase reactions of the type catalyzed by EC 2.4.2.6. -!- Formerly EC 2.4.2.23.

UniProtKB Entries (1)

P19971
TYPH_HUMAN
Homo sapiens
Thymidine phosphorylase

PDB Structure

PDB 1UOU
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal Structure of Human Thymidine Phosphorylase in Complex with a Small Molecule Inhibitor
Norman, R.A., Barry, S.T., Bate, M., Breed, J., Colls, J.G., Ernill, R.J., Luke, R.W.A., Minshull, C.A., Mcalister, M.S.B., Mccall, E.J., Mcmicken, H.H.J., Paterson, D.S., Timms, D., Tucker, J.A., Pauptit, R.A.
Structure