CATH Classification

Domain Context

CATH Clusters

Superfamily 3.40.50.20
Functional Family Lysine biosynthesis enzyme LysX

Enzyme Information

6.3.2.43
[Lysine-biosynthesis-protein LysW]--L-2-aminoadipate ligase.
based on mapping to UniProt Q5SH23
ATP + [lysine-biosynthesis-protein LysW]-C-terminal-L-glutamate + L-2- aminoadipate = ADP + phosphate + [lysine-biosynthesis-protein LysW]-C- terminal-gamma-(L-2-aminoadip-2-yl)-L-glutamate.
-!- The enzymes from the thermophilic bacterium Thermus thermophilus and the thermophilic archaea Sulfolobus acidocaldarius and Sulfolobus tokodaii protect the amino group of L-2-aminoadipate by conjugation to the carrier protein LysW. -!- This reaction is part of the lysine biosynthesis pathway in these organisms. -!- Formerly EC 6.3.2.n4.

UniProtKB Entries (1)

Q5SH23
LYSX_THET8
Thermus thermophilus HB8
Alpha-aminoadipate--LysW ligase LysX

PDB Structure

PDB 1UC8
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Crystal Structure of a Lysine Biosynthesis Enzyme, LysX, from Thermus thermophilus HB8
Sakai, H., Vassylyeva, M.N., Matsuura, T., Sekine, S., Gotoh, K., Nishiyama, M., Terada, T., Shirouzu, M., Kuramitsu, S., Vassylyev, D.G., Yokoyama, S.
J.Mol.Biol.