CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.1820 | Alpha/Beta hydrolase fold, catalytic domain |
Domain Context
CATH Clusters
| Superfamily | 3.40.50.1820 |
| Functional Family | 2-hydroxy-6-oxononadienedioate/2-hydroxy-6-oxononatrienedioate hydrolase 2 |
Enzyme Information
| 3.7.1.14 |
2-hydroxy-6-oxonona-2,4-dienedioate hydrolase.
based on mapping to UniProt P77044
(1) (2Z,4E)-2-hydroxy-6-oxonona-2,4-diene-1,9-dioate + H(2)O = (2Z)-2- hydroxypenta-2,4-dienoate + succinate. (2) (2Z,4E,7E)-2-hydroxy-6-oxonona-2,4,7-triene-1,9-dioate + H(2)O = (2Z)-2-hydroxypenta-2,4-dienoate + fumarate.
-!- This enzyme catalyzes a step in a pathway of phenylpropanoid compounds degradation. -!- The first step of the enzyme mechanism involves a reversible keto- enol tautomerization. -!- Formerly EC 3.7.1.n1.
|
UniProtKB Entries (1)
| P77044 |
MHPC_ECOLI
Escherichia coli K-12
2-hydroxy-6-oxononadienedioate/2-hydroxy-6-oxononatrienedioate hydrolase
|
PDB Structure
| PDB | 1U2E |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
The Structure of the C-C Bond Hydrolase MhpC Provides Insights into its Catalytic Mechanism
J.Mol.Biol.
|