CATH Classification

Domain Context

CATH Clusters

Superfamily Cytochrome P450
Functional Family Cytochrome P450 family monooxygenase

Enzyme Information
1,8-cineole 2-exo-monooxygenase.
based on mapping to UniProt P08684
1,8-cineole + NADPH + O(2) = 2-exo-hydroxy-1,8-cineole + NADP(+) + H(2)O.
-!- The mammalian enzyme, expressed in liver microsomes, performs a variety of oxidation reactions of structurally unrelated compounds, including stereoids, fatty acids, and xenobiotics. -!- Cf. EC, EC and EC
Albendazole monooxygenase.
based on mapping to UniProt P08684
Albendazole + NADPH + O(2) = albendazole S-oxide + NADP(+) + H(2)O.
Taurochenodeoxycholate 6-alpha-hydroxylase.
based on mapping to UniProt P08684
(1) Taurochenodeoxycholate + NADPH + O(2) = taurohyocholate + NADP(+) + H(2)O. (2) Lithocholate + NADPH + O(2) = hyodeoxycholate + NADP(+) + H(2)O.
-!- Requires cytochrome b5 for maximal activity. -!- Acts on taurochenodeoxycholate, taurodeoxycholate and less readily on lithocholate and chenodeoxycholate. -!- In adult pig (Sus scrofa), hyocholic acid replaces cholic acid as a primary bile acid.
Unspecific monooxygenase.
based on mapping to UniProt P08684
RH + [reduced NADPH--hemoprotein reductase] + O(2) = ROH + [oxidized NADPH--hemoprotein reductase] + H(2)O.
-!- Acts on a wide range of substrates including many xenobiotics, steroids, fatty acids, vitamins and prostaglandins; reactions catalyzed include hydroxylation, epoxidation, N-oxidation, sulfooxidation, N-, S- and O-dealkylations, desulfation, deamination, and reduction of azo, nitro and N-oxide groups. -!- Together with EC, it forms a system in which two reducing equivalents are supplied by NADPH. -!- Some of the reactions attributed to EC belong here. -!- Formerly EC, EC, EC and EC
Quinine 3-monooxygenase.
based on mapping to UniProt P08684
Quinine + NADPH + O(2) = 3-hydroxyquinine + NADP(+) + H(2)O.
With NADH or NADPH as one donor, and incorporation of one atom of oxygen.
based on mapping to UniProt P08684

UniProtKB Entries (1)

Homo sapiens
Cytochrome P450 3A4

PDB Structure

External Links
Organism Escherichia
Primary Citation
The Structure of Human Microsomal Cytochrome P450 3A4 Determined by X-ray Crystallography to 2.05-A Resolution
Yano, J.K., Wester, M.R., Schoch, G.A., Griffin, K.J., Stout, C.D., Johnson, E.F.