CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
1 | Mainly Alpha |
|
1.10 | Orthogonal Bundle |
|
1.10.630 | Cytochrome p450 |
|
1.10.630.10 | Cytochrome P450 |
Domain Context
CATH Clusters
| Superfamily | Cytochrome P450 |
| Functional Family | Cytochrome P450 family monooxygenase |
Enzyme Information
| 1.14.13.157 |
1,8-cineole 2-exo-monooxygenase.
based on mapping to UniProt P08684
1,8-cineole + NADPH + O(2) = 2-exo-hydroxy-1,8-cineole + NADP(+) + H(2)O.
-!- The mammalian enzyme, expressed in liver microsomes, performs a variety of oxidation reactions of structurally unrelated compounds, including stereoids, fatty acids, and xenobiotics. -!- Cf. EC 1.14.13.97, EC 1.14.13.67 and EC 1.14.13.32.
|
| 1.14.13.32 |
Albendazole monooxygenase.
based on mapping to UniProt P08684
Albendazole + NADPH + O(2) = albendazole S-oxide + NADP(+) + H(2)O.
|
| 1.14.13.- |
With NADH or NADPH as one donor, and incorporation of one atom of oxygen.
based on mapping to UniProt P08684
|
| 1.14.13.67 |
Quinine 3-monooxygenase.
based on mapping to UniProt P08684
Quinine + NADPH + O(2) = 3-hydroxyquinine + NADP(+) + H(2)O.
|
| 1.14.13.97 |
Taurochenodeoxycholate 6-alpha-hydroxylase.
based on mapping to UniProt P08684
(1) Taurochenodeoxycholate + NADPH + O(2) = taurohyocholate + NADP(+) + H(2)O. (2) Lithocholate + NADPH + O(2) = hyodeoxycholate + NADP(+) + H(2)O.
-!- Requires cytochrome b5 for maximal activity. -!- Acts on taurochenodeoxycholate, taurodeoxycholate and less readily on lithocholate and chenodeoxycholate. -!- In adult pig (Sus scrofa), hyocholic acid replaces cholic acid as a primary bile acid.
|
| 1.14.14.1 |
Unspecific monooxygenase.
based on mapping to UniProt P08684
RH + [reduced NADPH--hemoprotein reductase] + O(2) = ROH + [oxidized NADPH--hemoprotein reductase] + H(2)O.
-!- Acts on a wide range of substrates including many xenobiotics, steroids, fatty acids, vitamins and prostaglandins; reactions catalyzed include hydroxylation, epoxidation, N-oxidation, sulfooxidation, N-, S- and O-dealkylations, desulfation, deamination, and reduction of azo, nitro and N-oxide groups. -!- Together with EC 1.6.2.4, it forms a system in which two reducing equivalents are supplied by NADPH. -!- Some of the reactions attributed to EC 1.14.15.3 belong here. -!- Formerly EC 1.14.1.1, EC 1.14.14.2, EC 1.14.99.8 and EC 1.99.1.1.
|
UniProtKB Entries (1)
| P08684 |
CP3A4_HUMAN
Homo sapiens
Cytochrome P450 3A4
|
PDB Structure
| PDB | 1TQN |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
The Structure of Human Microsomal Cytochrome P450 3A4 Determined by X-ray Crystallography to 2.05-A Resolution
J.Biol.Chem.
|