CATH Classification

Domain Context

CATH Clusters

Functional Family Geranylgeranyl transferase type-1 subunit beta

Enzyme Information
Protein geranylgeranyltransferase type I.
based on mapping to UniProt P53610
Geranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl- protein + diphosphate.
-!- This enzyme, along with EC and EC, constitutes the protein prenyltransferase family of enzymes. -!- Catalyzes the formation of a thioether linkage between the C-1 atom of the geranylgeranyl group and a cysteine residue fourth from the C-terminus of the protein. -!- These protein acceptors have the C-terminal sequence CA(1)A(2)X, where the terminal residue, X, is preferably leucine; serine, methionine, alanine or glutamine makes the protein a substrate for EC -!- The enzymes are relaxed in specificity for A(1), but cannot act if A(2) is aromatic. -!- Known targets of this enzyme include most gamma-subunits of heterotrimeric G proteins and Ras-related GTPases such as members of the Ras and Rac/Rho families. -!- The Zn(2+) is required for peptide, but not for isoprenoid, substrate binding.

UniProtKB Entries (1)

Rattus norvegicus
Geranylgeranyl transferase type-1 subunit beta

PDB Structure

External Links
Organism Spodoptera
Primary Citation
Crystallographic analysis of CaaX prenyltransferases complexed with substrates defines rules of protein substrate selectivity.
Reid, T.S., Terry, K.L., Casey, P.J., Beese, L.S.