CATH Classification

Domain Context

CATH Clusters

Superfamily Trigger factor ribosome-binding domain
Functional Family Cell division trigger factor

Enzyme Information
Peptidylprolyl isomerase.
based on mapping to UniProt Q9KQS5
Peptidylproline (omega=180) = peptidylproline (omega=0).
-!- The first type of this enzyme found proved to be the protein cyclophilin, which binds the immunosuppressant cyclosporin A. -!- Other distinct families of the enzyme exist, one being FK-506 binding proteins (FKBP) and another that includes parvulin from Escherichia coli. -!- The three families are structurally unrelated and can be distinguished by being inhibited by cyclosporin A, FK-506 and 5-hydroxy-1,4-naphthoquinone, respectively.

UniProtKB Entries (1)

Vibrio cholerae O1 biovar El Tor str. N16961
Trigger factor

PDB Structure

PDB 1T11
External Links
Organism Escherichia
Primary Citation
The crystal structure of ribosomal chaperone trigger factor from Vibrio cholerae.
Ludlam, A.V., Moore, B.A., Xu, Z.