CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
1 | Mainly Alpha |
|
1.10 | Orthogonal Bundle |
|
1.10.530 | Lysozyme |
|
1.10.530.10 |
Domain Context
CATH Clusters
| Superfamily | 1.10.530.10 |
| Functional Family | Soluble lytic murein transglycosylase |
Enzyme Information
| 4.2.2.n1 |
Peptidoglycan lytic exotransglycosylase.
based on mapping to UniProt P0AGC3
Exolytic cleavage of the (1->4)-beta-glycosidic linkage between N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (GlcNAc) residues in peptidoglycan, from either the reducing or the non-reducing ends of the peptidoglycan chains, with concomitant formation of a 1,6-anhydrobond in the MurNAc residue.
|
| 3.2.1.- |
Glycosidases, i.e. enzymes hydrolyzing O- and S-glycosyl compounds.
based on mapping to UniProt P0AGC3
|
| 4.2.2.1 |
Hyaluronate lyase.
based on mapping to UniProt P0AGC3
Cleaves hyaluronate chains at a beta-D-GlcNAc-(1->4)-beta-D-GlcA bond, ultimately breaking the polysaccharide down to 3-(4-deoxy-beta-D-gluc-4- enuronosyl)-N-acetyl-D-glucosamine.
-!- The enzyme catalyzes the degradation of hyaluronan by a beta- elimination reaction. -!- Also acts on chondroitin. -!- The product is more systematically known as 3-(4-deoxy-alpha-L-threo- hex-4-enopyranosyluronic acid)-2-acetamido-2-deoxy-D-glucose. -!- Formerly EC 4.2.99.1.
|
| 4.2.2.- |
Acting on polysaccharides.
based on mapping to UniProt P0AGC3
|
UniProtKB Entries (1)
| P0AGC3 |
SLT_ECOLI
Escherichia coli K-12
Soluble lytic murein transglycosylase
|
PDB Structure
| PDB | 1QSA |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
High resolution crystal structures of the Escherichia coli lytic transglycosylase Slt70 and its complex with a peptidoglycan fragment.
J.Mol.Biol.
|