CATH Classification

Domain Context

CATH Clusters

Superfamily Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module
Functional Family NAD(P)H-flavin reductase

Enzyme Information

1.5.1.29
Transferred entry: 1.5.1.38, 1.5.1.39 and 1.5.1.41.
based on mapping to UniProt P0AEN1
1.16.1.3
Aquacobalamin reductase.
based on mapping to UniProt P0AEN1
2 cob(II)alamin + NAD(+) + 2 H(2)O = 2 aquacob(III)alamin + NADH.
-!- Formerly EC 1.6.99.8.
1.5.1.41
Riboflavin reductase (NAD(P)H).
based on mapping to UniProt P0AEN1
Reduced riboflavin + NAD(P)(+) = riboflavin + NAD(P)H.
-!- Catalyzes the reduction of soluble flavins by reduced pyridine nucleotides. -!- Highest activity with riboflavin. -!- When NADH is used as acceptor, the enzyme can also utilize FMN and FAD as substrates, with lower activity than riboflavin. -!- When NADPH is used as acceptor, the enzyme has a very low activity with FMN and no activity with FAD. -!- Formerly EC 1.5.1.29 and EC 1.6.8.1.
1.5.1.-
With NAD(+) or NADP(+) as acceptor.
based on mapping to UniProt P0AEN1
1.6.8.-
With a flavin as acceptor.
based on mapping to UniProt P0AEN1

UniProtKB Entries (1)

P0AEN1
FRE_ECOLI
Escherichia coli K-12
NAD(P)H-flavin reductase

PDB Structure

PDB 1QFJ
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Crystal structure of NAD(P)H:flavin oxidoreductase from Escherichia coli.
Ingelman, M., Ramaswamy, S., Niviere, V., Fontecave, M., Eklund, H.
Biochemistry