CATH Classification
Level | CATH Code | Description |
---|---|---|
3 | Alpha Beta | |
3.40 | 3-Layer(aba) Sandwich | |
3.40.50 | Rossmann fold | |
3.40.50.720 | NAD(P)-binding Rossmann-like Domain |
Domain Context
CATH Clusters
Superfamily | NAD(P)-binding Rossmann-like Domain |
Functional Family | Putative quinone oxidoreductase YhdH |
Enzyme Information
1.6.5.- |
With a quinone or similar compound as acceptor.
based on mapping to UniProt P26646
|
1.3.1.84 |
Acrylyl-CoA reductase (NADPH).
based on mapping to UniProt P26646
Propanoyl-CoA + NADP(+) = acrylyl-CoA + NADPH.
-!- Catalyzes a step in the 3-hydroxypropanoate/4-hydroxybutyrate cycle, an autotrophic CO(2) fixation pathway found in some thermoacidophilic archaea. -!- The reaction is catalyzed in the opposite direction to that shown. -!- The enzyme from Sulfolobus tokodaii does not act on either NADH or crotonyl-CoA. -!- Different from EC 1.3.1.8, which acts only on enoyl-CoA derivatives of carbon chain length 4 to 16.
|
1.1.1.284 |
S-(hydroxymethyl)glutathione dehydrogenase.
based on mapping to UniProt P26646
S-(hydroxymethyl)glutathione + NAD(P)(+) = S-formylglutathione + NAD(P)H.
-!- The substrate, S-(hydroxymethyl)glutathione, forms spontaneously from glutathione and formaldehyde; its rate of formation is increased in some bacteria by the presence of EC 4.4.1.22. -!- Forms part of the pathway that detoxifies formaldehyde, since the product is hydrolyzed by EC 3.1.2.12. -!- Also specifically reduces S-nitrosylglutathione. -!- Formerly EC 1.2.1.1.
|
UniProtKB Entries (1)
P26646 |
ACUI_ECOLI
Escherichia coli K-12
Probable acrylyl-CoA reductase AcuI
|
PDB Structure
PDB | 1O89 |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | |
Primary Citation |
Structure of the Escherichia Coli Yhdh, a Putative Quinone Oxidoreductase
Acta Crystallogr.,Sect.D
|