CATH Classification

Domain Context

CATH Clusters

Superfamily NAD(P)-binding Rossmann-like Domain
Functional Family Shikimate dehydrogenase (NADP(+))

Enzyme Information

1.1.1.282
Quinate/shikimate dehydrogenase.
based on mapping to UniProt P0A6D5
(1) L-quinate + NAD(P)(+) = 3-dehydroquinate + NAD(P)H. (2) Shikimate + NAD(P)(+) = 3-dehydroshikimate + NAD(P)H.
-!- This is the second shikimate dehydrogenase enzyme found in Escherichia coli and differs from EC 1.1.1.25, in that it can use both quinate and shikimate as substrate and either NAD(+) or NADP(+) as acceptor.

UniProtKB Entries (1)

P0A6D5
YDIB_ECOLI
Escherichia coli K-12
Quinate/shikimate dehydrogenase

PDB Structure

PDB 1NPD
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
The 2.3-A crystal structure of the shikimate 5-dehydrogenase orthologue YdiB from Escherichia coli suggests a novel catalytic environment for an NAD-dependent dehydrogenase
Benach, J., Lee, I., Edstrom, W., Kuzin, A.P., Chiang, Y., Acton, T.B., Montelione, G.T., Hunt, J.F.
J.Biol.Chem.