CATH Classification

Domain Context

CATH Clusters

Superfamily 3.40.50.970
Functional Family 2-oxoglutarate dehydrogenase E1 component

Enzyme Information

1.2.4.1
Pyruvate dehydrogenase (acetyl-transferring).
based on mapping to UniProt P08559
Pyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine = [dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO(2).
-!- It is a component (in multiple copies) of the multienzyme pyruvate dehydrogenase complex in which it is bound to a core of molecules of EC 2.3.1.12, which also binds multiple copies of EC 1.8.1.4. -!- It does not act on free lipoamide or lipoyllysine, but only on the lipoyllysine residue in EC 2.3.1.12.

UniProtKB Entries (1)

P11177
ODPB_HUMAN
Homo sapiens
Pyruvate dehydrogenase E1 component subunit beta, mitochondrial

PDB Structure

PDB 1NI4
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Structural Basis for Flip-Flop Action of Thiamin Pyrophosphate-Dependent Enzymes Revealed by Human Pyruvate Dehydrogenase
Ciszak, E.M., Korotchkina, L.G., Dominiak, P.M., Sidhu, S., Patel, M.S.
J.Biol.Chem.