CATH Classification
Domain Context
CATH Clusters
Superfamily | 3.90.1200.10 |
Functional Family | Fusion protein, Feo |
Enzyme Information
2.7.1.95 |
Kanamycin kinase.
based on mapping to UniProt P00552
ATP + kanamycin = ADP + kanamycin 3'-phosphate.
-!- Also acts on the antibiotics neomycin, paromomycin, neamine, paromamine, vistamycin and gentamicin A. -!- An enzyme from Pseudomonas aeruginosa also acts on butirosin.
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2.7.1.87 |
Streptomycin 3''-kinase.
based on mapping to UniProt P00552
ATP + streptomycin = ADP + streptomycin 3''-phosphate.
-!- Also phosphorylates dihydrostreptomycin, 3'-deoxydihydrostreptomycin and their 6-phosphates.
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UniProtKB Entries (1)
P00552 |
KKA2_KLEPN
Klebsiella pneumoniae
Aminoglycoside 3'-phosphotransferase
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PDB Structure
PDB | 1ND4 |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | Escherichia |
Primary Citation |
The crystal structure of aminoglycoside-3'-phosphotransferase-IIa, an enzyme responsible for antibiotic resistance
J.Mol.Biol.
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