CATH Classification

Domain Context

CATH Clusters

Superfamily Phosphorylase Kinase; domain 1
Functional Family Fusion protein, Feo

Enzyme Information

2.7.1.95
Kanamycin kinase.
based on mapping to UniProt P00552
ATP + kanamycin = ADP + kanamycin 3'-phosphate.
-!- Also acts on the antibiotics neomycin, paromomycin, neamine, paromamine, vistamycin and gentamicin A. -!- An enzyme from Pseudomonas aeruginosa also acts on butirosin.
2.7.1.87
Streptomycin 3''-kinase.
based on mapping to UniProt P00552
ATP + streptomycin = ADP + streptomycin 3''-phosphate.
-!- Also phosphorylates dihydrostreptomycin, 3'-deoxydihydrostreptomycin and their 6-phosphates.

UniProtKB Entries (1)

P00552
KKA2_KLEPN
Klebsiella pneumoniae
Aminoglycoside 3'-phosphotransferase

PDB Structure

PDB 1ND4
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
The crystal structure of aminoglycoside-3'-phosphotransferase-IIa, an enzyme responsible for antibiotic resistance
Nurizzo, D., Shewry, S.C., Perlin, M.H., Brown, S.A., Dholakia, J.N., Fuchs, R.L., Deva, T., Baker, E.N., Smith, C.A.
J.Mol.Biol.