CATH Classification

Domain Context

CATH Clusters

Superfamily Transferase(Phosphotransferase) domain 1
Functional Family Receptor tyrosine-protein kinase erbB-4

Enzyme Information

2.7.10.1
Receptor protein-tyrosine kinase.
based on mapping to UniProt P00533
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
-!- The receptor protein-tyrosine kinases, which can be defined as having a transmembrane domain, are a large and diverse multigene family found only in metazoans. -!- In the human genome, 58 receptor-type protein-tyrosine kinases have been identified and these are distributed into 20 subfamilies. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

P00533
EGFR_HUMAN
Homo sapiens
Epidermal growth factor receptor

PDB Structure

PDB 1M14
External Links
Method X-RAY DIFFRACTION
Organism Spodoptera
Primary Citation
Structure of the epidermal growth factor receptor kinase domain alone and in complex with a 4-anilinoquinazoline inhibitor.
Stamos, J., Sliwkowski, M.X., Eigenbrot, C.
J.Biol.Chem.