CATH Classification

Domain Context

CATH Clusters

Superfamily Phosphorylase Kinase; domain 1
Functional Family Muscle, skeletal receptor tyrosine-protein kinase

Enzyme Information

2.7.10.1
Receptor protein-tyrosine kinase.
based on mapping to UniProt Q62838
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
-!- The receptor protein-tyrosine kinases, which can be defined as having a transmembrane domain, are a large and diverse multigene family found only in metazoans. -!- In the human genome, 58 receptor-type protein-tyrosine kinases have been identified and these are distributed into 20 subfamilies. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

Q62838
MUSK_RAT
Rattus norvegicus
Muscle, skeletal receptor tyrosine protein kinase

PDB Structure

PDB 1LUF
External Links
Method X-RAY DIFFRACTION
Organism Spodoptera
Primary Citation
Crystal structure of the MuSK tyrosine kinase: insights into receptor autoregulation.
Till, J.H., Becerra, M., Watty, A., Lu, Y., Ma, Y., Neubert, T.A., Burden, S.J., Hubbard, S.R.
Structure