CATH Classification

Domain Context

CATH Clusters

Superfamily Collagenase (Catalytic Domain)
Functional Family Anthrax lethal factor endopeptidase

Enzyme Information
Anthrax lethal factor endopeptidase.
based on mapping to UniProt P15917
Preferred amino acids around the cleavage site can be denoted BBBBxHx-|-H, in which B denotes Arg or Lys, H denotes a hydrophobic amino acid, and x is any amino acid. The only known protein substrates are mitogen-activated protein (MAP) kinase kinases.
-!- From the bacterium Bacilus anthracis that causes anthrax. -!- One of three proteins that are collectively termed anthrax toxin. -!- Cleaves several MAP kinase kinases near their N-termini, preventing them from phosphorylating the downstream mitogen-activated protein kinases. -!- Belongs to peptidase family M34.

UniProtKB Entries (1)

Bacillus anthracis
Lethal factor

PDB Structure

External Links
Organism Bacillus
Primary Citation
Crystal structure of the anthrax lethal factor.
Pannifer, A.D., Wong, T.Y., Schwarzenbacher, R., Renatus, M., Petosa, C., Bienkowska, J., Lacy, D.B., Collier, R.J., Park, S., Leppla, S.H., Hanna, P., Liddington, R.C.