CATH Classification

Domain Context

CATH Clusters

Superfamily Calcium-transporting ATPase, cytoplasmic domain N
Functional Family Calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type

Enzyme Information

3.6.3.8
Calcium-transporting ATPase.
based on mapping to UniProt P04191
ATP + H(2)O + Ca(2+)(Side 1) = ADP + phosphate + Ca(2+)(Side 2).
-!- P-type ATPase that undergoes covalent phosphorylation during the transport cycle. -!- This enzyme family comprises three types of Ca(2+)-transporting enzymes that are found in the plasma membrane, the sarcoplasmic reticulum and in Saccharomyces cerevisiae. -!- The first and third transport one ion per ATP hydrolyzed, whereas the second transports two ions. -!- Formerly EC 3.6.1.38.

UniProtKB Entries (1)

P04191
AT2A1_RABIT
Oryctolagus cuniculus
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1

PDB Structure

PDB 1IWO
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural changes in the calcium pump accompanying the dissociation of calcium
Toyoshima, C., Nomura, H.
Nature