CATH Classification

Domain Context

CATH Clusters

Superfamily Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain
Functional Family Holliday junction DNA helicase RuvB

Enzyme Information

3.6.4.12
DNA helicase.
based on mapping to UniProt Q56313
ATP + H(2)O = ADP + phosphate.
-!- DNA helicases utilize the energy from ATP hydrolysis to unwind double-stranded DNA. -!- Some of them unwind duplex DNA with a 3' to 5' polarity (1,3,5,8), other show 5' to 3' polarity (10,11,12,13) or unwind DNA in both directions (14,15). -!- Some helicases unwind DNA as well as RNA (4,9). -!- May be identical with EC 3.6.4.13 (RNA helicase).

UniProtKB Entries (1)

Q56313
RUVB_THEMA
Thermotoga maritima MSB8
Holliday junction ATP-dependent DNA helicase RuvB

PDB Structure

PDB 1IN4
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Structure and mechanism of the RuvB Holliday junction branch migration motor.
Putnam, C.D., Clancy, S.B., Tsuruta, H., Gonzalez, S., Wetmur, J.G., Tainer, J.A.
J.Mol.Biol.