CATH Classification

Domain Context

CATH Clusters

Superfamily NAD(P)-binding Rossmann-like Domain
Functional Family Dihydropteridine reductase

Enzyme Information

1.5.1.34
6,7-dihydropteridine reductase.
based on mapping to UniProt P09417
A 5,6,7,8-tetrahydropteridine + NAD(P)(+) = a 6,7-dihydropteridine + NAD(P)H.
-!- The substrate is the quinonoid form of dihydropteridine. -!- Not identical with EC 1.5.1.3. -!- Formerly EC 1.6.99.7 and EC 1.6.99.10.

UniProtKB Entries (1)

P09417
DHPR_HUMAN
Homo sapiens
Dihydropteridine reductase

PDB Structure

PDB 1HDR
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
The crystallographic structure of a human dihydropteridine reductase NADH binary complex expressed in Escherichia coli by a cDNA constructed from its rat homologue.
Su, Y., Varughese, K.I., Xuong, N.H., Bray, T.L., Roche, D.J., Whiteley, J.M.
J.Biol.Chem.