CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.420 | Ricin (A subunit); domain 1 |
|
3.40.420.10 | Ricin (A subunit), domain 1 |
Domain Context
CATH Clusters
| Superfamily | Ricin (A subunit), domain 1 |
| Functional Family | Shiga toxin subunit A |
Enzyme Information
| 3.2.2.22 |
rRNA N-glycosylase.
based on mapping to UniProt Q9FBI2
Endohydrolysis of the N-glycosidic bond at one specific adenosine on the 28S rRNA.
-!- Ricin A-chain and related toxins show this activity. -!- Naked rRNA is attacked more slowly than rRNA in intact ribosomes. -!- Naked rRNA from Escherichia coli is cleaved at a corresponding position.
|
UniProtKB Entries (1)
| Q7BQ98 |
STXB_SHIDY
Shigella dysenteriae
Shiga toxin subunit B
|
PDB Structure
| PDB | 1DM0 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
Crystal structure of the holotoxin from Shigella dysenteriae at 2.5 A resolution.
Nat.Struct.Biol.
|