CATH Domain 1dfoA02

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.90	Alpha-Beta Complex
	3.90.1150	Aspartate Aminotransferase, domain 1
	3.90.1150.10	Aspartate Aminotransferase, domain 1

Domain Context

CATH Clusters

Superfamily	Aspartate Aminotransferase, domain 1
Functional Family	Serine hydroxymethyltransferase 2

Enzyme Information

2.1.2.1

Glycine hydroxymethyltransferase.

based on mapping to UniProt P0A825

5,10-methylenetetrahydrofolate + glycine + H(2)O = tetrahydrofolate + L-serine.

-!- Also catalyzes the reaction of glycine with acetaldehyde to form L-threonine, and with 4-trimethylammoniobutanal to form 3-hydroxy- N(6),N(6),N(6)-trimethyl-L-lysine.

UniProtKB Entries (1)

P0A825

GLYA_ECOLI

Escherichia coli K-12

Serine hydroxymethyltransferase

PDB Structure

PDB	1DFO
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism	Escherichia
Primary Citation	Crystal structure at 2.4 A resolution of E. coli serine hydroxymethyltransferase in complex with glycine substrate and 5-formyl tetrahydrofolate. Scarsdale, J.N., Radaev, S., Kazanina, G., Schirch, V., Wright, H.T. J.Mol.Biol.