CATH Classification

Domain Context

CATH Clusters

Superfamily Topoisomerase I, domain 2
Functional Family Putative DNA topoisomerase I

Enzyme Information

5.99.1.2
DNA topoisomerase.
based on mapping to UniProt P06612
ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.
-!- Brings about the conversion of one topological isomer of DNA into another, e.g. the relaxation of superhelical turns in DNA, the interconversion of simple and knotted rings of single-stranded DNA, and the intertwisting of single-stranded rings of complementary sequences (cf. EC 5.99.1.3).

UniProtKB Entries (1)

P06612
TOP1_ECOLI
Escherichia coli K-12
DNA topoisomerase 1

PDB Structure

PDB 1CY0
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Protein-nucleotide interactions in E. coli DNA topoisomerase I.
Feinberg, H., Changela, A., Mondragon, A.
Nat.Struct.Biol.