CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
1 | Mainly Alpha |
|
1.10 | Orthogonal Bundle |
|
1.10.460 | Topoisomerase I; domain 2 |
|
1.10.460.10 | Topoisomerase I, domain 2 |
Domain Context
CATH Clusters
| Superfamily | Topoisomerase I, domain 2 |
| Functional Family | Putative DNA topoisomerase I |
Enzyme Information
| 5.99.1.2 |
DNA topoisomerase.
based on mapping to UniProt P06612
ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.
-!- Brings about the conversion of one topological isomer of DNA into another, e.g. the relaxation of superhelical turns in DNA, the interconversion of simple and knotted rings of single-stranded DNA, and the intertwisting of single-stranded rings of complementary sequences (cf. EC 5.99.1.3).
|
UniProtKB Entries (1)
| P06612 |
TOP1_ECOLI
Escherichia coli K-12
DNA topoisomerase 1
|
PDB Structure
| PDB | 1CY0 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
Protein-nucleotide interactions in E. coli DNA topoisomerase I.
Nat.Struct.Biol.
|