CATH Classification

Domain Context

CATH Clusters

Superfamily Aspartate Aminotransferase, domain 1
Functional Family Tyrosine aminotransferase isoform 2

Enzyme Information

2.6.1.5
Tyrosine transaminase.
based on mapping to UniProt P33447
L-tyrosine + 2-oxoglutarate = 4-hydroxyphenylpyruvate + L-glutamate.
-!- L-phenylalanine can act instead of L-tyrosine. -!- The mitochondrial enzyme may be identical with EC 2.6.1.1. -!- The three isoenzymic forms are interconverted by EC 3.4.22.32 and EC 3.4.22.33. -!- The enzyme can also catalyze the final step in the methionine-salvage pathway of Klebsiella pneumoniae.

UniProtKB Entries (1)

P33447
ATTY_TRYCR
Trypanosoma cruzi
Tyrosine aminotransferase

PDB Structure

PDB 1BW0
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal structure of Trypanosoma cruzi tyrosine aminotransferase: substrate specificity is influenced by cofactor binding mode.
Blankenfeldt, W., Nowicki, C., Montemartini-Kalisz, M., Kalisz, H.M., Hecht, H.J.
Protein Sci.