CATH Classification

Domain Context

CATH Clusters

Superfamily 3.40.50.980
Functional Family Long-chain fatty-acid-CoA ligase fadD15

Enzyme Information

1.13.12.7
Photinus-luciferin 4-monooxygenase (ATP-hydrolyzing).
based on mapping to UniProt P08659
Photinus luciferin + O(2) + ATP = oxidized Photinus luciferin + CO(2) + AMP + diphosphate + light.
-!- Photinus (firefly) is a bioluminescent insect. -!- The first step in the reaction is the formation of an acid anhydride between the carboxylic group and AMP, with the release of diphosphate. -!- The enzyme may be assayed by measurement of light emission.

UniProtKB Entries (1)

P08659
LUCI_PHOPY
Photinus pyralis
Luciferin 4-monooxygenase

PDB Structure

PDB 1BA3
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Structural basis for the inhibition of firefly luciferase by a general anesthetic.
Franks, N.P., Jenkins, A., Conti, E., Lieb, W.R., Brick, P.
Biophys.J.