CATH Classification

Domain Context

CATH Clusters

Superfamily 3.40.50.970
Functional Family Putative pyruvate-flavodoxin oxidoreductase domain protein

Enzyme Information

1.2.7.1
Pyruvate synthase.
based on mapping to UniProt P94692
Pyruvate + CoA + 2 oxidized ferredoxin = acetyl-CoA + CO(2) + 2 reduced ferredoxin + 2 H(+).
-!- The enzyme also decarboxylates 2-oxobutanoate with lower efficiency, but shows no activity with 2-oxoglutarate. -!- This enzyme is a member of the 2-oxoacid oxidoreductases, a family of enzymes that oxidatively decarboxylate different 2-oxoacids to form their CoA derivatives, and are differentiated based on their substrate specificity. -!- For examples of other members of this family, see EC 1.2.7.3 and EC 1.2.7.7.

UniProtKB Entries (1)

P94692
POR_DESAF
Desulfovibrio africanus
Pyruvate synthase

PDB Structure

PDB 1B0P
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal structures of the key anaerobic enzyme pyruvate:ferredoxin oxidoreductase, free and in complex with pyruvate.
Chabriere, E., Charon, M.H., Volbeda, A., Pieulle, L., Hatchikian, E.C., Fontecilla-Camps, J.C.
Nat.Struct.Biol.