CATH Classification

Domain Context

CATH Clusters

Superfamily NAD(P)-binding Rossmann-like Domain
Functional Family Bifunctional protein FolD 2

Enzyme Information

3.5.4.9
Methenyltetrahydrofolate cyclohydrolase.
based on mapping to UniProt P24186
5,10-methenyltetrahydrofolate + H(2)O = 10-formyltetrahydrofolate.
1.5.1.5
Methylenetetrahydrofolate dehydrogenase (NADP(+)).
based on mapping to UniProt P24186
5,10-methylenetetrahydrofolate + NADP(+) = 5,10- methenyltetrahydrofolate + NADPH.

UniProtKB Entries (1)

P24186
FOLD_ECOLI
Escherichia coli K-12
Bifunctional protein FolD

PDB Structure

PDB 1B0A
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
The crystal structure of a bacterial, bifunctional 5,10 methylene-tetrahydrofolate dehydrogenase/cyclohydrolase.
Shen, B.W., Dyer, D.H., Huang, J.Y., D'Ari, L., Rabinowitz, J., Stoddard, B.L.
Protein Sci.