CATH Classification

Domain Context

CATH Clusters

Superfamily Nucleotide cyclase
Functional Family Adenylate cyclase type 2

Enzyme Information

4.6.1.1
Adenylate cyclase.
based on mapping to UniProt P30803
ATP = 3',5'-cyclic AMP + diphosphate.
-!- Also acts on dATP to form 3',5'-cyclic dAMP. -!- Requires pyruvate. -!- Activated by NAD(+) in presence of EC 2.4.2.31.

UniProtKB Entries (3)

P26769
ADCY2_RAT
Rattus norvegicus
Adenylate cyclase type 2
P30803
ADCY5_CANLF
Canis lupus familiaris
Adenylate cyclase type 5
P04896
GNAS2_BOVIN
Bos taurus
Guanine nucleotide-binding protein G(s) subunit alpha isoforms short

PDB Structure

PDB 1AZS
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Crystal structure of the catalytic domains of adenylyl cyclase in a complex with Gsalpha.GTPgammaS.
Tesmer, J.J., Sunahara, R.K., Gilman, A.G., Sprang, S.R.
Science