CATH Classification

Domain Context

CATH Clusters

Superfamily NAD(P)-binding Rossmann-like Domain
Functional Family Glyceraldehyde 3-phosphate dehydrogenase, glycosomal

Enzyme Information

1.2.1.12
Glyceraldehyde-3-phosphate dehydrogenase (phosphorylating).
based on mapping to UniProt Q27890
D-glyceraldehyde 3-phosphate + phosphate + NAD(+) = 3-phospho-D-glyceroyl phosphate + NADH.
-!- Also acts very slowly on D-glyceraldehyde and some other aldehydes. -!- Thiols can replace phosphate.

UniProtKB Entries (1)

Q27890
G3PG_LEIME
Leishmania mexicana
Glyceraldehyde-3-phosphate dehydrogenase, glycosomal

PDB Structure

PDB 1A7K
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Crystal structure of Leishmania mexicana glycosomal glyceraldehyde-3-phosphate dehydrogenase in a new crystal form confirms the putative physiological active site structure.
Kim, H., Hol, W.G.
J.Mol.Biol.