CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
1 | Mainly Alpha |
|
1.20 | Up-down Bundle |
|
1.20.120 | Four Helix Bundle (Hemerythrin (Met), subunit A) |
|
1.20.120.380 | Type 1-topoisomerase catalytic fragment, domain 2 |
Domain Context
CATH Clusters
| Superfamily | Type 1-topoisomerase catalytic fragment, domain 2 |
| Functional Family | DNA topoisomerase 1 |
Enzyme Information
| 5.99.1.2 |
DNA topoisomerase.
based on mapping to UniProt P68698
ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.
-!- Brings about the conversion of one topological isomer of DNA into another, e.g. the relaxation of superhelical turns in DNA, the interconversion of simple and knotted rings of single-stranded DNA, and the intertwisting of single-stranded rings of complementary sequences (cf. EC 5.99.1.3).
|
UniProtKB Entries (1)
| P68698 |
TOP1_VACCW
Vaccinia virus WR
DNA topoisomerase 1B
|
PDB Structure
| PDB | 1A41 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | Escherichia |
| Primary Citation |
Conservation of structure and mechanism between eukaryotic topoisomerase I and site-specific recombinases.
Cell(Cambridge,Mass.)
|