CATH Classification

Domain Context

CATH Clusters

Superfamily Enolpyruvate transferase domain
Functional Family UDP-N-acetylglucosamine 1-carboxyvinyltransferase 1

Enzyme Information

2.5.1.7
UDP-N-acetylglucosamine 1-carboxyvinyltransferase.
based on mapping to UniProt P0A749
Phosphoenolpyruvate + UDP-N-acetyl-alpha-D-glucosamine = phosphate + UDP- N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine.

UniProtKB Entries (1)

P0A749
MURA_ECOLI
Escherichia coli K-12
UDP-N-acetylglucosamine 1-carboxyvinyltransferase

PDB Structure

PDB 1A2N
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Stereochemical course of enzymatic enolpyruvyl transfer and catalytic conformation of the active site revealed by the crystal structure of the fluorinated analogue of the reaction tetrahedral intermediate bound to the active site of the C115A mutant of MurA
Skarzynski, T., Kim, D.H., Lees, W.J., Walsh, C.T., Duncan, K.
Biochemistry