CATH Classification

Domain Context

CATH Clusters

Superfamily SH2 domain
Functional Family Proto-oncogene tyrosine-protein kinase Src

Enzyme Information
Non-specific protein-tyrosine kinase.
based on mapping to UniProt P12931
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
-!- Unlike EC, this protein-tyrosine kinase does not have a transmembrane domain. -!- In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into 10 families. -!- Formerly EC

UniProtKB Entries (1)

Homo sapiens
Proto-oncogene tyrosine-protein kinase Src

PDB Structure

PDB 1A07
External Links
Organism Escherichia
Primary Citation
Peptide ligands of pp60(c-src) SH2 domains: a thermodynamic and structural study.
Charifson, P.S., Shewchuk, L.M., Rocque, W., Hummel, C.W., Jordan, S.R., Mohr, C., Pacofsky, G.J., Peel, M.R., Rodriguez, M., Sternbach, D.D., Consler, T.G.