The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was: waiting to be named.

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: Response regulator

This superfamily comprises structural domains with a Rossmann fold found in a variety of proteins and enzymes, including response regulators such as LacI-like transcriptional regulators PMID:7973627,PMID:9865945, CheY-type chemotaxis response regulators INTERPRO:IPR011006,PMID:9030562,PMID:12080332, (multi-)sensor (hybrid) histidine kinase response regulators PMID:17005198, phosphate regulon response regulators (PhoP, PhoB), periplasmic binding proteins (PBPs) such as sugar-binding proteins PMID:17473016,PMID:19744923, ABC (ATP-binding cassette) transporters and other solute binding proteins (SBPs) PMID:23606130,PMID:23404400, histidine kinases, protein tyrosine phosphatases (kinases) PMID:21871460,PMID:24909685,PMID:11573087.

This domain can perform several functions such as ligand recognition, sugar binding, DNA binding, protein phosphorylation, chemotaxis, quorum sensing PMID:11823863, signal transduction.

Pfam clan [PfamClan:CL0144]

GO Diversity

Unique GO annotations
1325 Unique GO terms

EC Diversity

Unique EC annotations
32 Unique EC terms

Species Diversity

Unique species annotations
25789 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Domains: 2543
Domain clusters (>95% seq id): 616
Domain clusters (>35% seq id): 402
Unique PDBs: 964
Structural Clusters (5A): 22
Structural Clusters (9A): 8
FunFam Clusters: 1676
Unique EC: 32
Unique GO: 1325
Unique Species: 25789