The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Vaccinia Virus protein VP39
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Browse Functional Families

ID Function Family (FunFam) Name Total Sequences Enzyme? Structure? Structural Representative PDB Sites? Alignment Diversity (0-100)
135486
42790
EC
3D
3tkaA01 - 94.2
135633
34027
EC
3D
4obwA00 - 90.9
134647
25772
EC
3D
2fpoA00 - 90.5
132728
24089
EC
- - 51.7
135599
23817
3D
3grzB00 - 87.7
135988
22298
EC
3D
1t43A02 - 93.3
135553
19141
EC
3D
2o05A02 - 88.9
135561
19031
EC
3D
1sqfA04 - 91.8
135365
17845
EC
3D
1zq9A01 - 97.4
135373
adenine-specific
16800
EC
3D
2g1pA01 - 85.7
131392
15772
EC
3D
4bluA00 - 75.1
136062
AFU_orthologue AFUA_3G05390
14299
EC
3D
1i1nA00 - 92.7
134643
uracil-C(5
12788
EC
3D
3bt7A01 - 90.2
135359
11987
EC
- - 85.8
135136
uracil(1939 5
11326
EC
3D
1uwvA02 - 82.9
135516
10486
EC
3D
1jsxA00 - 88.4
136020
10239
EC
3D
1booA00 - 95.1
135942
guanine-N(7
9757
EC
3D
3ckkA01 - 90.6
134908
8995
EC
3D
1wg8A01 - 89.2
134902
mo5U34
8926 - - 97.4
135866
CheR
8837
EC
3D
1af7A02 - 97.7
135941
Uracil-5-
8816
EC
- - 85.3
135513
Guanine-N(7 Modular protein
8572
EC
3D
3dxxA00 - 87.2
135355
8173
EC
3D
1qamA01 - 92.5
135687
7895
EC
3D
2pjdA02 - 95.2
135331
7784
EC
3D
4kdcA00 - 88.4
135832
6960
EC
- - 94.2
135578
6821
EC
3D
10mhA01 - 98.1
136074
6471
EC
3D
2ckdA00 - 95.1
135322
6241
EC
3D
3c0kA03 - 96.2
135860
6196
EC
3D
3v8vA02 - 92.7
136163
5146
EC
- - 93.1
135472
4854
EC
3D
2p35A01 - 93.6
135185
cmo5U34
4846
EC
3D
4iwnA00 - 96.9
135667
4829
EC
3D
3awiA01 - 87.2
6069
4809
EC
3D
1p91A00 - 71.5
133742
4432
EC
3D
2xvaA00 - 83.4
135816
uracil(747 5
4280
EC
3D
2jjqA02 - 90.6
134970
4256
EC
- - 92.1
135689
3941
EC
3D
2pkwA02 - 92.9
134182
3845
EC
3D
3v8vA04 - 91.2
136177
3825
EC
3D
3hnrA00 - 84.2
134583
Val adenine(37
3729
EC
- - 96.9
135817
3540
EC
3D
1fp1D02 - 90.2
135514
3485
EC
3D
2avdA00 - 85.3
135838
3287
EC
3D
4atnA03 - 95.3
135575
3146
EC
- - 88.0
135603
2791
EC
3D
2ipxA02 - 81.2
71168
15 decarboxylating
2607
EC
- - 3.0
136149
2600
EC
3D
2bzgA00 - 90.5
5031
2575
EC
- - 36.1
134891
2562
EC
- - 92.8
135896
2398
EC
- - 73.0
40797
2230
EC
- - 90.7
135178
2213
EC
- - 82.3
135844
1859
EC
3D
5cm2Z00 - 83.8
135586
1744 - - 93.9
135244
1727
EC
- - 80.4
135011
1715
EC
3D
2zw9A01 - 88.2
135748
1686
EC
3D
2pxxA00 - 71.3
136201
1604
EC
3D
3bgvA00 - 86.0
135023
guanine(37
1514
EC
- - 83.2
133690
1450
EC
- - 81.3
135393
1377 - - 94.4
134733
1338 - - 87.1
135515
1258
EC
- - 94.2
136037
1248
EC
3D
1nw3A02 - 90.7
134568
guanine-N(7
1186
EC
3D
4qttB00 - 85.2
135236
1184
3D
2b9eA02 - 77.3
136367
1176
EC
3D
1nkvA00 - 96.2
135963
1124
3D
4lecA00 - 83.9
135527
1040
EC
3D
1m6yA01 - 95.0
136107
1022
EC
- - 88.9
132574
1006 - - 40.9
134858
966
EC
3D
2ex4A00 - 85.8
135593
964
EC
- - 93.0
136171
903 - - 86.0
135188
845
EC
- - 92.2
135346
801
EC
- - 91.0
135612
795
EC
3D
1dctA01 - 92.8
135779
Decarboxylating
784
EC
- - 93.1
135475
777
EC
- - 91.5
135912
739 - - 86.7
136041
690
EC
3D
3a7eA00 - 95.1
133860
681
EC
- - 85.3
82459
649
EC
- - 5.3
133399
646
EC
- - 85.2
136209
Uracil-5-
618
EC
- - 87.9
135518
604 - - 92.9
134717
587
3D
4gc5A01 - 78.8
135509
571
3D
2zfuA02 - 78.4
135349
548
EC
3D
4gqbA02 - 86.9
131378
544 - - 74.8
131974
519
EC
- - 65.7
131377
517
EC
3D
1g55A02 - 85.4
133759
Cytosine-5
517
EC
3D
2qrvA01 - 84.0
134895
498
EC
- - 89.5
37349
495
EC
- - 74.6
136421
474 - - 96.5
136186
472
EC
- - 91.7
26414
446
EC
- - 80.5
136362
441
EC
- - 90.2
131390
436
EC
3D
1l1eA00 - 28.3
17897
cmo5U34
430 - - 33.4
135781
420
EC
3D
2cmgA02 - 74.1
136335
412
EC
3D
3egiA00 - 84.1
135280
411 - - 58.9
135876
409
EC
3D
4a6dA02 - 85.7
28414
398
EC
- - 57.5
135943
guanine(26 2
397
EC
3D
3axsA01 - 84.8
133865
guanine(10
395 - - 87.9
22081
391
EC
- - 47.9
132853
390
EC
- - 67.8
135672
cytosine-5
387
EC
3D
3pt9A02 - 79.4
135635
383
EC
3D
3ftcA01 - 97.8
68677
382
EC
- - 49.0
135936
377
EC
3D
4c4aA01 - 94.8
135792
374
EC
3D
2a14A00 - 92.2
136168
362 - - 92.7
135377
341
EC
- - 94.1
65671
Guanine46-N7-
324
EC
- - 83.7
136295
322
EC
- - 99.2
131342
321
EC
3D
1kpiA00 - 25.1
135764
316
EC
- - 87.7
132883
316
EC
3D
3evaA00 - 93.5
62961
305
EC
3D
5ks2A00 - 27.0
134443
301
EC
- - 84.0
135519
295
EC
- - 94.7
135410
290
EC
- - 89.9
3465
290 - - 0.4
135933
285
EC
- - 93.7
132920
Cytosine-5
276
EC
- - 88.1
133687
274
EC
- - 90.4
108357
267 - - 91.5
61500
256
EC
- - 0.0
136408
253
3D
1i4wA01 - 98.4
136036
guanine-N(7
251
EC
- - 50.0
136361
247
3D
3ofjA00 - 92.1
135357
235
EC
- - 90.2
136196
233
3D
2ld4A00 - 90.7
136377
233
EC
3D
4pwyA00 - 93.9
135797
233 - - 88.9
135099
229
EC
- - 8.2
100101
228 - - 2.0
17463
228
EC
- - 2.0
133424
227 - - 0.7
135174
226
EC
- - 95.0
69786
225
EC
- - 0.0
134333
223
EC
- - 86.1
12109
221
EC
3D
2ar0A02 - 26.5
136018
guanine(26 2
218
EC
3D
2dulA01 - 94.8
136212
217
EC
3D
1r8xA02 - 94.3
134282
+3 oxidation state
214
EC
- - 92.6
134318
207
EC
- - 95.8
135913
203
EC
3D
4xcxA00 - 85.2
136200
201
EC
- - 77.6
128790
200
EC
- - 41.8
134432
200 - - 80.0
26384
199
3D
2ip2A02 - 0.0
136063
198 - - 92.0
75307
196 - - 0.0
135229
195 - - 91.0
54470
188
EC
3D
3c6kA03 - 86.7
133772
187 - - 83.4
135887
186
EC
- - 96.1
132550
183
EC
3D
1av6A00 - 83.1
37248
183
EC
- - 15.3
131649
183
EC
3D
1jqdA00 - 97.1
99927
182 - - 0.0
135325
182 - - 91.6
64133
176 - - 32.2
38434
171
EC
- - 0.0
134780
168
EC
- - 80.9
135688
165 - - 86.0
132593
163
EC
- - 64.2
131410
161
3D
2h00A00 - 55.6
135303
guanine(37
154
EC
- - 91.3
4324
154 - - 2.5
136066
151 - - 59.3
133012
149
EC
- - 87.9
135521
5-cytosine
148
EC
- - 84.7
44820
148 - - 85.2
92825
147
EC
- - 3.6
47268
Val adenine(37
146
EC
- - 6.6
135772
145
EC
- - 82.0
135767
138
EC
3D
4c4aA03 - 88.0
131210
137
EC
3D
3orhA00 - 79.3
131738
137
EC
3D
3vc1A00 - 65.6
75311
137 - - 1.1
102926
136 - - 0.0
136151
135
EC
- - 13.3
355
133
EC
- - 17.4
85157
132 - - 45.6
88140
131 - - 12.9
135918
129
EC
- - 93.6
135270
128 - - 83.1
4561
126
EC
- - 0.0
132663
126
EC
- - 35.6
132376
126
EC
- - 78.7
109972
125 - - 3.2
133018
123
EC
- - 90.3
127782
123 - - 71.4
3172
122
EC
3D
1kphA00 - 3.7
135485
122 - - 70.2
136147
120
EC
- - 87.2
2897
116
3D
2fk7A00 - 9.9
133311
116
EC
- - 56.4
133469
adenine(58 1
113
EC
3D
5eqjB02 - 85.9
135075
111
EC
- - 64.4
41003
SUN protein
110
EC
- - 13.0
132620
109
EC
- - 50.0
69206
Adenine(58 1
109 - - 80.1
75622
Irp2
107 - - 24.6
134392
106 - - 52.6
134352
101 - - 83.7
136140
101
EC
- - 42.5
135769
100
EC
- - 89.0
135353
99
EC
- - 84.1
101562
99
EC
- - 31.8
133310
94 - - 68.4
136189
N
2 2
94
EC
- - 89.5
55085
15 decarboxylating
91
EC
- - 9.0
51523
90
EC
- - 27.2
83715
89 - - 16.3
2234
88
EC
3D
1tpyA00 - 3.3
133326
88
3D
4fp9A02 - 72.2
136182
87
EC
- - 86.4
131742
86 - - 57.2
62979
85
EC
- - 0.6
135823
85 - - 70.4
60109
85
EC
3D
3b89A02 - 9.5
59339
Val adenine(37
83
EC
- - 8.1
136299
guanine-N(7
82
EC
- - 97.8
136473
82 - - 35.6
135292
82
EC
- - 72.8
135368
81
EC
- - 69.6
67721
81 - - 58.0
135928
80
EC
- - 79.2
132044
80
EC
- - 42.5
133356
79 - - 71.6
136406
78
EC
- - 93.1
135217
78
EC
- - 48.3
134465
78
EC
3D
2vz9A05 - 81.5
136174
AFU_orthologue; AFUA_4G03321
76
EC
- - 96.6
30677
adenine(58 1
75
EC
3D
5ccbA02 - 50.4
133565
75 - - 67.8
57526
73
EC
- - 2.3
135279
73
EC
- - 95.9
132772
70
EC
- - 64.9
135847
guanine(10
66
EC
- - 92.7
82442
66
EC
- - 0.0
34008
64
EC
- - 0.0
113
64
EC
- - 0.0
10631
64
EC
- - 6.3
72576
63
EC
3D
4ponA00 - 9.3
136106
62 - - 79.2
135480
61
EC
- - 79.6
135774
60 - - 75.0
132525
60
EC
- - 44.7
136024
59 - - 44.0
135384
57 - - 91.0
135409
55
EC
- - 87.5
16457
54
EC
- - 2.7
2774
53 - - 37.0
95582
53 - - 1.6
131191
53
EC
3D
3ieiA00 - 46.2
6132
52
EC
- - 3.0
136484
52
EC
- - 87.2
135762
51
EC
- - 76.0
43401
50 - - 5.2
91911
50
EC
- - 3.5
132767
50
EC
- - 43.6
132391
15 decarboxylating
50
EC
- - 9.7
13092
49 - - 0.0
42234
49 - - 0.0
7296
49
EC
- - 58.5
187
47
EC
- - 62.9
135902
guanine(37
46
EC
- - 85.4
134247
46
EC
3D
4qdjA00 - 57.3
36051
46
EC
- - 2.6
135732
15 decarboxylating
44
EC
3D
2yxdA00 - 86.5
43577
43 - - 1.1
62763
42
EC
3D
2iftA00 - 44.5
43910
42 - - 58.5
22186
40 - - 33.1
132673
40
EC
- - 17.3
38163
40
EC
- - 8.5
24777
40
3D
1xxlA00 - 19.3
8909
38 - - 0.4
16390
38
EC
3D
2okcA02 - 16.4
135588
38
EC
- - 4.3
127953
37 - - 24.7
58832
37
EC
- - 0.0
131908
35 - - 67.9
136027
35
EC
- - 91.5
43587
Val adenine(37
35
EC
- - 10.7
136220
adenine(58 1
35 - - 85.1
132449
32 - - 43.7
38382
29
EC
- - 11.0
134470
29 - - 31.4
59262
29 - - 58.9
134681
Val adenine(37
28
EC
- - 75.7
131851
27
EC
3D
1aqiA01 - 16.9
133630
27
EC
3D
2dpmA01 - 31.6
33380
27
EC
- - 10.1
133321
27 - - 56.1
135498
guanine(37
27
EC
- - 54.2
102790
27 - - 16.6
136360
26 - - 82.9
135677
adenine-specific
26
EC
- - 82.1
55132
25 - - 37.9
80100
25
EC
- - 0.0
135725
25 - - 44.4
135727
24
EC
- - 68.5
136417
24 - - 91.6
5072
24 - - 4.3
135624
23
EC
- - 88.4
56281
23
EC
- - 4.6
105810
22 - - 40.3
3176
22
EC
- - 0.4
100773
21
3D
3cjqA02 - 16.0
136046
21
EC
- - 83.8
54051
21
EC
- - 3.4
136248
21 - - 62.1
135858
guanine(1405 7
21
EC
3D
3lcuA02 - 92.5
126641
cytosine-5
20
EC
- - 13.1
48173
20
EC
- - 0.0
77208
19 - - 40.2
131238
19
EC
- - 31.8
135686
adenine(57 1 58 1
19
EC
3D
3lgaA02 - 75.6
135253
19
EC
3D
3ssmA02 - 22.0
94638
19
EC
- - 12.7
106694
18 - - 29.0
105668
18
EC
- - 31.6
133439
15 decarboxylating
18
EC
- - 20.8
91937
18 - - 2.1
136152
18
EC
- - 59.5
133571
17 - - 74.7
136389
17 - - 54.9
100770
17
EC
- - 1.1
86063
17
EC
- - 2.3
36048
17
EC
- - 23.0
81254
16 - - 0.0
61117
16 - - 0.0
75266
16 - - 0.0
131146
adenine(58 1
15
EC
- - 24.0
15861
15
EC
- - 10.1
116960
15 - - 27.6
24066
15
EC
- - 37.1
34271
15 - - 24.8
75315
15 - - 1.7
55088
15 - - 2.2
62954
14
EC
3D
2b25A02 - 25.1
84948
14
EC
- - 22.7
57518
13
EC
3D
3fuuA01 - 7.4
131783
13
EC
- - 7.7
14483
13
EC
- - 4.5
135978
12
EC
- - 80.6
99078
12 - - 28.9
60284
12 - - 23.4
12841
11 - - 4.1
82472
11
EC
- - 2.9
134500
11 - - 37.2
55620
11 - - 7.2
10589
10
EC
- - 0.6
23436
10
EC
- - 0.0
57502
adenine(58 1
10
EC
- - 9.4
17555
10 - - 15.9
134303
10
EC
3D
3bxoA01 - 32.2
43570
Val adenine(37
10
EC
- - 7.0
135154
guanine(37
10
EC
3D
2yx1A03 - 44.8
2271
10
EC
- - 3.4
135782
JCVI
9 - - 57.9
135723
9 - - 46.2
135805
9
EC
3D
1ej6A04 - 84.2
53914
9 - - 15.4
2818
9 - - 0.0
136120
9
EC
- - 41.6
126332
9 - - 2.8
29166
9
EC
- - 5.8
79221
9 - - 26.4
103227
9 - - 0.0
131942
9 - - 20.1
131873
Val adenine(37
8
EC
- - 16.2
47095
8
EC
- - 13.6
61461
Phe 4-demethylwyosine(37 7
8
EC
3D
3a25A02 - 13.1
132736
Val adenine(37
8
EC
- - 26.7
133478
8
EC
- - 40.7
58823
8 - - 3.0
28381
8 - - 12.1
136308
7
EC
- - 63.0
135814
7
EC
- - 40.5
99934
7
EC
- - 1.9
132899
7
EC
- - 4.4
98428
7 - - 10.5
133361
7 - - 8.4
47076
6
EC
- - 2.2
5561
Guanine-N(1
6
EC
- - 6.8
13128
6 - - 16.4
9421
6 - - 1.7
26918
6 - - 20.6
27007
6
EC
- - 1.1
102276
5
EC
- - 7.2
52118
5 - - 7.9
26328
5
EC
- - 1.0
78967
5
EC
- - 0.0
135369
5 - - 0.0
135251
5 - - 0.0
88226
5 - - 10.1
17879
5
EC
- - 22.5
23860
5 - - 5.4
135200
5
EC
- - 26.3
99065
5
EC
- - 0.8
131913
guanine-N(7
5
EC
- - 17.1
3466
5
EC
- - 7.2
11459
5 - - 16.7
135751
5 - - 37.2
8864
5 - - 22.5
77001
Val adenine(37
5
EC
- - 7.4
58793
5 - - 2.4
57647
4 - - 0.0
58836
Val adenine(37
4
EC
- - 0.0
13553
Phe 4-demethylwyosine(37 7
4
EC
3D
3a27A00 - 13.0
132654
4
EC
- - 0.0
90045
15 decarboxylating
4
EC
- - 0.0
113733
4 - - 0.0
31556
4 - - 13.1
76532
4 - - 0.0
11762
4 - - 2.7
101551
4 - - 0.0
135923
4
EC
- - 68.6
95564
4 - - 0.0
8362
4
EC
3D
1g60A00 - 8.7
11317
4
EC
- - 41.8
42362
4
3D
3a4tA02 - 0.0
135807
cytosine-5
4
EC
- - 27.6
100986
4 - - 0.0
38611
4
EC
- - 6.4
57103
4 - - 16.6
65713
4
EC
3D
3htxA03 - 7.2
134300
4 - - 9.4
135983
3
EC
- - 28.7
62921
adenine(58 1
3
EC
- - 0.6
24129
3 - - 14.5
107894
guanine-N(7
3
EC
- - 16.4
74805
3 - - 8.2
135935
3
EC
- - 36.0
12590
3
EC
- - 15.4
135130
3
EC
- - 10.7
61481
Val adenine(37
3
EC
- - 2.4
2942
3
EC
- - 7.6
82470
3 - - 3.0
133436
3
EC
- - 25.0
133610
3 - - 15.3
131805
3
EC
- - 12.5
118780
3 - - 0.9
17456
3
EC
- - 3.8
117582
3 - - 5.5
135648
3
EC
- - 22.4
46867
3 - - 10.8
127856
3 - - 11.2
69758
2
EC
- - 8.8
132708
2
EC
- - 28.5
55089
2 - - 5.6
132675
Val adenine(37
2
EC
- - 19.5
119967
2
EC
- - 0.0
118080
2 - - 14.9
84957
2
EC
- - 0.7
135730
2
EC
- - 37.4
132537
guanine-N(7
2
EC
- - 17.1
135801
adenine-N(1
2 - - 30.4
89095
2 - - 10.5
136274
2 - - 42.5
77785
2
EC
- - 0.7
103374
2 - - 11.6
132601
2
EC
- - 20.7
117632
2 - - 5.3
113574
2 - - 2.3
81650
2
EC
- - 2.9
132716
guanine(37
2
EC
- - 23.3
99925
2
EC
- - 16.1
12104
Adenine-specific
2
EC
- - 4.8
108363
2 - - 0.0
90329
2 - - 0.0
87584
2 - - 8.1
24403
2
EC
- - 1.7
110483
2 - - 0.6
93575
guanine(26 2
2
EC
- - 8.7
112785
2 - - 6.5
135071
15 decarboxylating
2
EC
- - 36.3
87190
2 - - 0.0
135845
guanine(10
2
EC
- - 37.2
132660
2 - - 23.0
114854
1 - - 0.0
125271
1 - - 0.0
83688
1 - - 0.0
28397
Val adenine(37
1
EC
- - 0.0
110973
1 - - 0.0
97319
1 - - 0.0
133312
1
EC
- - 0.0
111940
1
EC
- - 0.0
67238
1 - - 0.0
135915
adenine-specific
1
EC
- - 0.0
90042
1
EC
- - 0.0
112782
1
EC
- - 0.0
41002
Val adenine(37
1
EC
- - 0.0
136040
1
EC
- - 0.0
68447
guanine(37
1
EC
- - 0.0
33131
1 - - 0.0
53983
Val adenine(37
1
EC
- - 0.0
64395
1 - - 0.0
51543
Val adenine(37
1
EC
- - 0.0
48583
1 - - 0.0
38444
Val adenine(37
1
EC
- - 0.0
96461
1
EC
- - 0.0
58841
Val adenine(37
1
EC
- - 0.0
64350
1 - - 0.0
46033
1
EC
- - 0.0
87141
1
EC
- - 0.0
117053
1 - - 0.0
48229
guanine(2535 1
1
EC
- - 0.0
115565
1 - - 0.0
104740
1
EC
- - 0.0
61534
Val adenine(37
1
EC
- - 0.0
19018
1 - - 0.0
34046
1
EC
- - 0.0
128931
1 - - 0.0
136150
1
EC
- - 0.0
76531
1 - - 0.0
65686
1 - - 0.0
44560
1
EC
- - 0.0
25569
guanine(37
1
EC
- - 0.0
25557
1
EC
- - 0.0
130573
1 - - 0.0
76477
1
EC
- - 0.0
97315
1 - - 0.0
29130
1
EC
- - 0.0
136135
1
EC
- - 0.0
130238
1 - - 0.0
115141
1
EC
- - 0.0
30705
1
EC
- - 0.0
64971
1 - - 0.0
136340
Uracil-5-
1 - - 0.0
33108
1
EC
- - 0.0
90997
adenine(1408 1
1
EC
- - 0.0
81219
5,15
1
EC
- - 0.0
132726
1 - - 0.0
135798
1
EC
- - 0.0
135696
1 - - 0.0
47780
1
EC
- - 0.0
47124
1
EC
- - 0.0
93699
1 - - 0.0
12592
1
EC
- - 0.0
136133
1
EC
- - 0.0
58835
adenine(58 1
1
EC
- - 0.0
100775
1
EC
- - 0.0
99072
1 - - 0.0
128667
1 - - 0.0
27704
5
1 - - 0.0