The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Browse Functional Families

ID Function Family (FunFam) Name Total Sequences Enzyme? Structure? Structural Representative PDB Sites? Alignment Diversity (0-100)
22240
2792
3D
1gg3A01 - 91.6
22924
2234
EC
3D
3fssA02 - 92.0
22686
2193
EC
3D
1faoA00 - 95.0
22512
1756
EC
3D
2gcjA02 - 86.7
22306
1626
EC
3D
1ni2A03 - 97.6
22636
1577
EC
3D
1fgyA00 - 71.3
22238
1551
EC
3D
1h10A00 - 91.7
22383
1507
3D
2dkpA01 - 87.5
22902
1477
EC
3D
2mwnB00 - 79.9
22502
1371
3D
3hk0A02 - 86.5
22277
1223
3D
5efxA00 - 87.1
22597
1221
EC
3D
2rovA00 - 80.4
22132
1213
3D
1k5dB00 - 90.3
22319
1129
EC
3D
2dkqA01 - 97.2
22655
1039
EC
3D
1mkeA00 - 90.0
22816
1026 - - 90.1
22483
1021 - - 92.5
22084
1012
3D
1aqcA00 - 83.0
22614
1004
EC
- - 92.0
22097
954
3D
1evhA00 - 93.6
22949
929
EC
3D
2qklA00 - 79.6
21743
927
3D
2m38A00 - 79.0
22284
880 - - 87.1
22362
836
EC
3D
3qwmA00 - 89.6
22631
832 - - 96.5
8369
817 - - 73.4
22038
Drosophila
811
3D
1i7aA00 - 86.3
22603
810
EC
- - 89.0
22143
803
EC
3D
2ys1A00 - 93.8
22345
784 - - 87.3
22759
774
3D
1wi1A01 - 79.5
22557
751
EC
3D
4nswA02 - 76.0
22192
738 - - 88.5
22489
730 - - 82.9
22475
707
3D
4bbkA00 - 81.2
22263
Drosophila
706
3D
1m7eA00 - 86.0
22583
694
EC
3D
1lw3A01 - 83.1
22309
657
3D
4k2oA01 - 85.6
22122
656
3D
3fehA02 - 87.6
22525
625
3D
4wsfA00 - 88.8
22792
621 - - 88.4
22311
617
3D
1xcgA02 - 90.1
22962
612
EC
- - 91.5
21912
Drosophila
607
3D
1ddmA00 - 79.1
22800
607
EC
3D
2coaA01 - 80.4
22493
606 - - 68.0
22067
603 - - 86.3
22471
602
EC
- - 93.4
22481
592
3D
1irsA00 - 88.2
22027
586
3D
4gzuA03 - 82.6
22501
579
EC
3D
1b55A00 - 90.1
22654
574
EC
- - 94.8
22632
567
3D
2crfA01 - 87.8
22236
563
EC
3D
1tqzA01 - 87.1
22135
547
EC
- - 84.2
22911
544
3D
2dtcA00 - 78.9
22656
532
EC
3D
2cy4A00 - 94.4
22283
514 - - 80.9
22430
511
EC
3D
1v5uA00 - 90.4
22102
508
3D
3syxA00 - 86.9
22408
488
3D
2vszA02 - 93.1
22085
469
3D
2dfkA02 - 86.9
22162
469 - - 90.7
21964
452
3D
5c6rA00 - 85.4
22979
450 - - 97.1
22844
450 - - 94.6
22796
445
EC
3D
1w1dA00 - 83.8
22460
438 - - 91.6
22420
432
EC
- - 87.1
22252
426
3D
3d8dA00 - 88.3
22457
417
3D
1qqgA01 - 96.1
1026
411
EC
3D
1kz7A02 - 77.8
22299
409 - - 93.0
21755
408
3D
1ki1B02 - 74.9
415
408 - - 78.3
21800
406
EC
3D
1ntyA02 - 69.8
22307
404
3D
2vrwB02 - 88.2
22459
404
3D
1p5tA00 - 90.6
22580
403
3D
2y7bA00 - 95.6
22531
378 - - 88.8
22443
377
3D
1x1fA00 - 96.9
21767
375
3D
1eazA00 - 96.3
21746
373
3D
1v88A00 - 71.7
22266
361
EC
- - 95.3
5343
349 - - 75.2
21887
341
3D
2kcjA00 - 80.1
22336
341 - - 84.7
22091
334 - - 75.9
22660
330
EC
3D
1x05A00 - 83.1
22680
322 - - 82.9
22332
320
3D
1wguA01 - 76.7
21977
318
EC
3D
1bakA00 - 73.2
22254
312
3D
3tfmA01 - 71.3
22121
312
EC
- - 83.6
22092
307
3D
2ej8A00 - 87.4
22474
306
3D
2codA01 - 83.5
4504
305 - - 76.3
22338
294 - - 92.6
22476
291 - - 89.7
21879
283
3D
1pmsA00 - 69.0
1260
280
3D
1xkeA00 - 69.8
22643
278
3D
1z87A01 - 86.5
22286
277
EC
3D
3pvlA04 - 68.5
21737
276
EC
3D
4l6eA00 - 69.9
22201
258
EC
3D
2rgnB02 - 88.1
22139
258
3D
3ml4A02 - 66.3
21796
252 - - 78.8
22821
248 - - 98.0
13488
244
3D
3fehA03 - 66.7
7639
241
EC
- - 55.6
22381
239
3D
2dhkA01 - 88.3
19075
239
3D
3au4A04 - 81.6
2589
238
EC
- - 66.9
21950
234 - - 55.9
22384
234
EC
- - 88.6
21794
233
EC
- - 75.8
16390
232
3D
1j0wA00 - 29.9
6909
229 - - 61.2
22494
228 - - 87.0
21858
227
3D
4yonA02 - 65.6
21877
225
3D
4wj7A00 - 89.4
7860
213 - - 74.8
22606
210 - - 85.8
22781
209 - - 93.2
10927
206 - - 78.8
22372
205 - - 79.3
18037
205
EC
3D
1pfjA00 - 92.9
22047
203 - - 38.1
22500
203 - - 77.3
22101
202
3D
1u5eA02 - 69.7
2564
202 - - 41.6
22387
201 - - 58.8
17450
199 - - 60.9
2519
199 - - 70.6
22205
199 - - 80.6
21929
199
EC
- - 46.7
21866
196 - - 73.9
16685
195 - - 51.4
22072
195
3D
2dn6A00 - 80.9
7608
193 - - 61.0
21753
191 - - 70.8
22358
188 - - 89.0
21936
188 - - 65.1
22407
186 - - 81.5
21870
185 - - 67.9
22175
184
3D
2cofA00 - 76.0
1789
183 - - 80.2
21905
181
EC
- - 47.4
233
179 - - 75.2
16278
178 - - 22.9
22089
178
3D
2rsgA00 - 68.4
22522
176
3D
2d9wA01 - 92.5
22527
173
3D
4gzuA02 - 78.8
21930
171
3D
4h8sA02 - 64.9
21969
169 - - 55.6
12415
168
EC
- - 63.6
22487
167 - - 86.3
5346
162
3D
1v5mA00 - 82.5
21849
159 - - 59.7
22203
157 - - 64.5
7075
156
3D
1btnA00 - 71.1
21759
156 - - 78.0
10307
156
3D
3dxcA00 - 69.8
22339
155
3D
2q13A02 - 72.4
21966
155 - - 69.8
21947
155
3D
2dhjA00 - 63.9
22611
155
3D
3tfmA02 - 75.4
2111
154 - - 78.4
28
152
3D
1n3hA00 - 86.6
1046
152 - - 47.2
22630
151 - - 95.1
339
150 - - 29.6
22058
149
EC
- - 68.3
22394
149 - - 77.9
16149
149
3D
2d9xA01 - 51.2
22681
148
EC
- - 92.6
2410
147
EC
- - 35.4
21731
146
3D
3so6A00 - 69.2
21787
145
3D
3pp2A00 - 66.5
22330
145 - - 89.4
1956
142 - - 60.3
22798
142
3D
3u7dA03 - 85.9
21816
141 - - 67.4
22359
136 - - 83.2
17116
136
EC
- - 45.9
15731
135
3D
1wgqA00 - 61.0
2582
134
EC
- - 61.2
21766
134 - - 57.6
17120
131
EC
- - 56.2
8648
129
3D
3cxbB00 - 46.4
22232
129 - - 83.4
14572
125
EC
- - 28.8
22117
124
EC
- - 58.1
22442
123
EC
3D
1maiA00 - 79.6
21946
123 - - 67.3
12685
122 - - 5.4
7366
121 - - 31.9
679
121
3D
1rrpB00 - 48.6
890
121
3D
1foeA02 - 58.4
22488
121 - - 87.1
16394
120 - - 47.1
4246
120
3D
2z0qA02 - 35.2
22076
118 - - 92.3
3713
117 - - 40.6
14207
114
3D
1plsA00 - 79.9
14878
112 - - 35.9
21945
112
3D
3aj4A00 - 61.7
21762
112 - - 65.3
21791
112 - - 67.5
16396
111
3D
2yf0A01 - 43.8
22677
111 - - 86.6
21776
110 - - 61.1
4230
109 - - 58.2
21825
108 - - 68.4
13483
108
EC
- - 41.0
22906
107
EC
- - 84.8
22202
105 - - 74.0
21836
104 - - 82.0
22943
104 - - 88.8
1495
104
3D
2p0dA00 - 51.8
3536
103 - - 36.3
7425
102
3D
2ec1A00 - 41.7
22010
100
EC
- - 61.3
21942
99
EC
- - 43.4
7625
98 - - 17.5
6746
97 - - 50.8
5814
97 - - 58.1
11645
97
3D
2d9vA01 - 61.6
13853
96 - - 52.1
5406
95 - - 25.0
21814
95 - - 53.4
21764
93
3D
1u5dA00 - 55.7
21893
93 - - 65.2
9918
92 - - 55.6
13564
91 - - 22.8
22799
89 - - 39.8
8805
88 - - 56.6
4889
87
3D
4b6hA00 - 22.5
12932
87 - - 58.9
12210
85 - - 51.4
21951
84 - - 62.5
21937
84
3D
1zc3B00 - 63.6
22150
82 - - 69.0
21868
82 - - 40.8
7571
82 - - 32.8
21752
79 - - 47.8
13178
79 - - 48.3
22107
77 - - 63.4
22523
77 - - 85.7
10983
76 - - 27.0
21881
75 - - 69.6
22241
75 - - 71.7
3240
73 - - 71.2
15309
71 - - 38.4
21833
71 - - 57.1
22118
71 - - 72.2
22439
71 - - 46.6
21949
69 - - 81.3
7072
69 - - 55.7
8921
68 - - 27.8
18429
67 - - 51.8
2184
66 - - 63.8
7294
65
3D
1wjmA00 - 42.3
21832
65
3D
1v61A00 - 52.6
21976
64 - - 63.8
16370
62
EC
- - 30.9
21927
62 - - 46.4
22952
60 - - 58.3
10100
59 - - 55.0
1133
59
3D
3nsuA00 - 14.8
2844
58 - - 15.4
22128
58 - - 57.7
1375
57 - - 42.1
22211
57
3D
3ml4A01 - 56.9
6272
56 - - 38.7
3213
55
EC
- - 50.1
9213
55 - - 22.4
552
54 - - 33.2
22251
54 - - 73.4
2138
53 - - 18.3
21838
51 - - 34.9
22819
50 - - 50.0
22772
49 - - 91.3
22052
49 - - 43.6
12679
CENTD3
48 - - 51.5
22891
46 - - 44.9
22905
45 - - 30.0
14932
43
3D
1v5pA01 - 14.0
2001
43 - - 50.8
7046
42 - - 34.0
17449
42 - - 28.5
15694
41 - - 41.9
13346
40 - - 36.0
21779
40 - - 29.5
15682
38 - - 36.8
16476
38
EC
- - 44.0
2389
36 - - 18.0
13401
35
EC
- - 7.5
21809
34 - - 41.9
22023
34 - - 42.3
21844
33 - - 42.9
11050
33 - - 51.2
2770
33 - - 0.0
3539
33
EC
- - 27.0
21891
33 - - 37.6
4830
32 - - 16.2
21906
32 - - 48.9
21934
32 - - 41.5
8393
31 - - 21.5
21725
31 - - 34.8
21749
30 - -
9232
28 - - 2.3
11018
28 - - 16.0
16081
28 - - 1.0
10580
28
EC
- - 36.6
5739
27
EC
- - 14.7
21294
25
EC
- - 0.0
12813
25 - - 6.1
13484
25
EC
- - 15.4
16778
24 - - 23.9
8180
24 - - 32.7
21886
24 - - 62.2
1943
24 - - 51.5
17157
24
EC
- - 25.4
5425
22 - - 16.9
8398
22 - - 24.5
15722
20 - - 2.4
8498
19 - - 7.7
3059
19 - - 16.2
2920
19 - - 15.3
677
18 - - 37.5
2613
18 - - 16.7
22659
18 - - 41.5
18084
18 - - 15.5
5374
18
EC
- - 14.8
4508
17 - - 5.9
1496
17 - - 3.6
815
17 - - 11.6
5348
17
EC
- - 5.6
15363
16 - - 9.9
9600
16 - - 8.7
8855
16 - - 9.5
22592
16
EC
- - 60.7
18706
16 - - 10.4
13862
16 - - 9.1
8804
16 - - 3.3
22131
15
EC
- - 32.5
11901
15 - - 7.7
3435
15 - - 4.9
22030
15 - - 43.1
5993
15 - - 33.2
21965
15
3D
2k2jA00 - 1.9
10254
14
EC
- - 28.4
21875
14
EC
- - 29.7
6643
14 - - 28.5
4247
14 - - 7.9
17834
13 - - 10.1
16516
13 - - 26.1
8801
13 - - 9.9
7699
13 - - 14.1
10554
12
EC
- - 20.1
8224
12
3D
1droA00 - 21.1
21961
12 - - 55.1
18443
12
EC
- - 16.9
11602
12 - - 2.0
8920
12 - - 23.0
13257
12 - - 3.6
16718
12 - - 14.8
8397
12
3D
1fhoA00 - 21.7
16375
11 - - 21.8
4041
11 - - 9.5
15991
11 - - 3.9
965
10 - - 29.6
7087
10 - - 15.7
9309
10 - - 3.0
47
10 - - 14.0
1759
9 - - 12.6
10990
9 - - 1.2
11828
9
EC
- - 6.1
11447
9
EC
- - 7.0
20807
9
EC
- - 1.5
3791
8 - - 4.2
9944
8 - - 7.6
11391
8 - - 13.1
7762
8 - - 1.0
7945
8 - - 6.0
1777
8
EC
- - 1.0
4841
8 - - 0.0
12682
8
EC
- - 5.1
22612
8 - - 0.9
21747
8 - - 47.6
431
7 - - 20.3
7016
7 - - 17.0
6463
PH
7 - - 8.3
13558
7 - - 6.4
18416
7 - - 10.4
16158
7 - - 13.6
11824
6 - - 14.2
11427
6 - - 12.5
19728
6
EC
- - 2.6
12061
6 - - 24.8
468
6 - - 7.9
17761
6 - - 11.9
17540
6
EC
- - 19.0
8863
6 - - 21.6
103
6 - - 13.6
8056
6 - - 18.5
21847
6 - - 31.0
8266
6 - - 12.0
4012
5 - - 4.7
11041
5 - - 8.9
2146
5 - - 7.9
18086
5
EC
- - 1.3
3768
5 - - 7.7
5659
5 - - 10.5
16403
5
EC
- - 13.0
16777
5 - - 12.7
21911
5 - - 47.3
21799
4 - - 21.3
9651
4 - - 13.7
17456
4
EC
- - 6.5
10430
4 - - 9.1
6637
4 - - 1.6
17852
4 - - 0.0
11497
4 - - 0.0
22300
4
EC
- - 1.1
18124
4 - - 7.9
6381
4
EC
- - 8.6
1291
4 - - 0.0
216
4 - - 6.2
17764
4
EC
- - 11.8
22046
4
3D
1xr0B01 - 26.8
11076
PH
3 - - 13.1
22788
3
EC
- - 58.6
4174
3 - - 0.0
22789
3 - - 60.2
8491
3 - - 0.0
12259
3 - - 0.0
15687
3 - - 1.1
22553
3 - - 59.0
3765
3 - - 0.0
1300
3
EC
- - 1.6
3870
3 - - 3.0
1246
2 - - 0.9
20124
2 - - 8.0
22769
2 - - 45.0
22782
2 - - 41.8
8802
2 - - 0.0
14688
2 - - 0.0
1519
2 - - 0.0
21922
2 - - 8.9
12252
2
EC
- - 10.8
22627
2 - - 15.3
17242
2 - - 4.4
3766
2 - - 0.0
19417
2 - - 6.6
12681
2 - - 0.0
4538
2 - - 0.0
1545
2 - - 0.0
22657
2 - - 40.0
11401
2 - - 11.3
20874
2 - - 12.9
22585
2 - - 42.0
8040
1 - - 0.0
21628
1 - - 0.0
11554
1 - - 0.0
22424
1 - - 0.0
22790
1 - - 0.0
9667
1
EC
- - 0.0
5896
1 - - 0.0
1407
1 - -
6676
1 - - 0.0
6641
1 - - 0.0
888
1 - - 0.0
3626
1 - - 0.0
15307
1 - - 0.0
11816
1 - - 0.0
21248
1 - - 0.0
20477
1 - - 0.0
17760
1
EC
- - 0.0
8066
1 - - 0.0
17758
1 - - 0.0
22936
1 - - 0.0
5344
1 - - 0.0
22947
1 - - 0.0
22044
1 - - 0.0
1694
1 - - 0.0
18704
1 - - 0.0
14433
1 - -
22264
1 - - 0.0
17453
1 - - 0.0
11400
1 - - 0.0
4572
1 - - 0.0