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CATH Superfamily 1.20.1420.30

NCX, central ion-binding region

The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

"
NCX, central ion-binding region
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Browse Functional Families

ID Function Family (FunFam) Name Total Sequences Enzyme? Structure? Structural Representative PDB Sites? Alignment Diversity (0-100)
1
sodium/calcium exchanger 1 isoform X1
696 - - 66.4
2
Sodium/potassium/calcium exchanger 2 isoform 1
526 - - 76.0
3
sodium/calcium exchanger 1 isoform X1
505 - - 72.4
4
Sodium/potassium/calcium exchanger 2 isoform 1
441 - - 83.8
5
sodium/potassium/calcium exchanger 3 isoform X1
329 - - 76.1
6
sodium/potassium/calcium exchanger 4 isoform X1
252 - - 68.5
7
Vacuolar calcium ion transporter
228 - - 92.7
8
Vacuolar cation/proton exchanger
227 - - 80.9
9
sodium/potassium/calcium exchanger 5 isoform X2
195 - - 97.0
10
Na+/Ca+ antiporter, CaCA family
164
3D
 5hyaA02 - 88.2
11
Vacuolar calcium ion transporter
131 - - 85.0
12
Vacuolar cation/proton exchanger
129 - - 82.2
13
Calcium permease family membrane transporter
117 - - 76.2
14
Cation/H+ exchanger protein 2
107 - - 96.0
15
sodium/potassium/calcium exchanger 5 isoform X2
106 - - 81.8
16
Membrane bound cation transporter
68 - - 77.4
17
Calcium permease family membrane transporter
53 - - 64.3
18
Sodium/potassium/calcium exchanger 2
45 - - 76.1
19
Sodium/calcium exchanger NCL2
38 - - 86.7
20
Vacuolar cation/proton exchanger
36 - - 72.2
21
Vacuolar calcium ion transporter
35 - - 81.5
22
sodium/potassium/calcium exchanger 2 isoform X4
34 - - 61.8
23
Mitochondrial sodium/calcium exchanger protein
34 - - 65.2
24
Calcium/proton exchanger, variant
32 - - 78.6
25
sodium/potassium/calcium exchanger 6, mitochondrial isoform X3
28 - - 67.3
26
Vacuolar calcium ion transporter
27 - - 73.8
27
Vacuolar calcium ion transporter
24 - - 81.9
28
Cation/calcium exchanger 5
23 - - 77.9
29
Calcium/proton exchanger
19 - - 51.2
30
Cation/calcium exchanger 4
15 - - 53.3
31
K+-dependent Na+/Ca+ exchanger related-protein
14 - - 72.5
32
Ca2: Cation Antiporter
CaCA
12 - - 10.0
33
YDL206W-like protein
11 - - 12.0
35
ECM27p protein
10 - - 2.5
34
YDL206W-like protein
10 - - 2.7
36
Sodium/calcium exchanger MaX1
9 - - 79.1
37
Predicted protein
9 - - 48.8
39
WGS project CABT00000000 data, contig 2.3
8 - - 68.0
40
Probable sodium/calcium exchanger antiporter
8 - - 70.2
38
Solute carrier family 24 member 6a
8 - - 34.0
41
Na/Ca eXchangers
6 - - 46.5
42
Zydeco, isoform F
6 - - 13.6
43
Ecm27p
5 - - 2.0
44
sodium/potassium/calcium exchanger 3 isoform X2
5 - - 18.8
46
Vacuolar calcium ion transporter
5 - - 6.4
45
Solute carrier family 24 member 4
5 - - 19.6
48
Cation/calcium exchanger 5
4 - - 11.1
49
Ca
2+ +
4 - - 5.2
50
Hypothetical_protein_-_conserved
4 - - 8.2
51
Na+/Ca+ antiporter, CaCA family
4 - - 34.2
47
Probable sodium/calcium exchanger antiporter
4 - - 79.4
55
Uncharacterized protein, isoform F
3 - - 5.5
56
Uncharacterized protein, isoform F
3 - - 8.3
52
Potassium-dependent sodium-calcium exchanger, putative
3 - - 76.8
53
Sodium/calcium exchanger membrane region
3 - - 0.0
54
Sodium/calcium exchanger membrane region
3 - - 0.0
61
Na+/Ca+ antiporter, CaCA family
2 - - 0.0
68
Uncharacterized protein
2 - - 27.2
60
Na+/Ca+ antiporter, CaCA family
2 - - 0.0
69
Uncharacterized protein
2 - - 12.2
63
Sodium/potassium/calcium exchanger 4
2 - - 0.0
62
Predicted protein
2 - - 10.7
70
Potassium-dependent sodium-calcium exchanger, putative
2 - - 43.8
71
Sodium-calcium exchanger
2 - - 0.0
58
Predicted protein
2 - - 34.0
57
Uncharacterized protein
2 - - 29.7
74
Uncharacterized protein
2 - - 0.0
64
Sodium/potassium/calcium exchanger Nckx30C
2 - - 0.0
65
Ca2+:Cation Antiporter
CaCA
2 - - 7.8
75
Uncharacterized protein
2 - - 0.0
66
Na/Ca eXchangers
2 - - 33.3
59
Ca
2+ +
2 - - 42.8
72
Na+/Ca+ antiporter, CaCA family
2 - - 8.0
73
Vacuolar H+\/Ca2+ exchanger
2 - - 0.0
67
Uncharacterized protein
2 - - 33.1
78
Uncharacterized protein
1 - - 0.0
112
Uncharacterized protein
1 - - 0.0
89
Uncharacterized protein
1 - - 0.0
91
Potassium-dependent sodium-calcium exchanger, putative
1 - - 0.0
80
Ca
2+ +
1 - - 0.0
92
Uncharacterized protein
1 - - 0.0
105
Uncharacterized protein
1 - - 0.0
111
Uncharacterized protein
1 - - 0.0
82
Uncharacterized protein
1 - - 0.0
99
Uncharacterized protein
1 - - 0.0
90
Potassium-dependent sodium-calcium exchanger, putative
1 - - 0.0
81
Uncharacterized protein
1 - - 0.0
76
Putative cation exchanger C3A12.06c
1 - - 0.0
110
Potassium-dependent sodium-calcium exchanger, putative
1 - - 0.0
102
Potassium-dependent sodium-calcium exchanger, putative
1 - - 0.0
84
Uncharacterized protein
1 - - 0.0
77
Ca
2+ +
1 - - 0.0
100
Uncharacterized protein
1 - - 0.0
79
Uncharacterized protein
1 - - 0.0
93
Ca2+/Na+ antiporter
1 - - 0.0
103
Vacuolar cation/proton exchanger 2
1 - - 0.0
83
Uncharacterized protein
1 - - 0.0
101
Uncharacterized protein
1 - - 0.0
96
Uncharacterized protein
1 - - 0.0
108
AGAP010974-PA
1 - - 0.0
85
Putative cation exchanger C3A12.06c
1 - - 0.0
94
Uncharacterized protein
1 - - 0.0
109
Uncharacterized protein
1 - - 0.0
95
Uncharacterized protein
1 - - 0.0
106
Sodium/calcium exchanger membrane region
1 - - 0.0
86
AGAP008342-PA
1 - - 0.0
98
Uncharacterized protein
1 - - 0.0
107
AGAP010976-PA
1 - - 0.0
87
Uncharacterized protein
1 - - 0.0
104
Uncharacterized protein
1 - - 0.0
97
Potassium-dependent sodium-calcium exchanger, putative
1 - - 0.0
88
Uncharacterized protein
1 - - 0.0