The name of this superfamily has been modified since the most recent official CATH+ release (v4_3_0). At the point of the last release, this superfamily was named:

NCX, central ion-binding region

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Superfamily: NCX, central ion-binding region

Na+/Ca2+ exchanger (NCX) are membrane transporters that play an essential role in maintaining the homeostasis of cytosolic Ca2+ for cell signalling. Ca2+ is moved into or out of the cytosol depending on Na+ concentration NCX is a symmetrical structure containing ten transmembrane helices, divided in two halves with a similar structure but opposite orientation. Based on its symmetry, NCX is able to catalyse bidirectional ion-exchange reactions. Four ion-binding sites cluster at the centre of the protein: one specific for Ca2+ and three that likely bind Na+. Two passageways allow for Na+ and Ca2+ access to the central ion-binding sites from the extracellular side.

This superfamily entry represents the large central ion-binding region made up of 8 transmembrane helices, also known as the intracellular regulatory domain

PFAM:PF01699, INTERPRO:IPR004837,DOI:10.1126/science.1215759,DOI:10.1038/nsmb.3230

GO Diversity

Unique GO annotations
186 Unique GO terms

EC Diversity

Unique EC annotations
0 Unique EC terms

Species Diversity

Unique species annotations
9884 Unique species

Sequence/Structure Diversity

Overview of the sequence / structure diversity of this superfamily compared to other superfamilies in CATH. Click on the chart to view the data in more detail.

Superfamily Summary

A general summary of information for this superfamily.
Domains: 18
Domain clusters (>95% seq id): 1
Domain clusters (>35% seq id): 1
Unique PDBs: 17
Structural Clusters (5A): 1
Structural Clusters (9A): 1
FunFam Clusters: 112
Unique EC:
Unique GO: 186
Unique Species: 9884