The name of this superfamily has been modified since the most recent official CATH+ release (v4_2_0). At the point of the last release, this superfamily was named:

"
Homeodomain-like
".

Functional Families

Overview of the Structural Clusters (SC) and Functional Families within this CATH Superfamily. Clusters with a representative structure are represented by a filled circle.

Browse Functional Families

ID Function Family (FunFam) Name Total Sequences Enzyme? Structure? Structural Representative PDB Sites? Alignment Diversity (0-100)
31818
56915 - - 46.6
59653
55980 - - 19.1
124059
41208
3D
1d5yA01 - 76.7
124375
41188
3D
1d5yA02 - 82.4
39476
30484 - - 38.1
17896
21471
3D
1bl0A01 - 62.3
16076
20772
3D
1bl0A02 - 36.9
124137
19452
3D
1etkA00 - 99.8
28357
18953 - - 38.0
30626
15610
3D
2k9sA00 - 26.7
125075
13876
3D
3locA01 - 97.4
69789
13547 - - 0.0
123451
10254
EC
3D
1ig7A00 - 89.2
124774
9474
EC
3D
2i10A01 - 96.7
124643
9428 - - 47.8
82779
8433 - - 14.3
124729
8200
EC
3D
1g2hA00 - 94.8
122996
I
8112
EC
3D
1ntcA00 - 51.9
124399
7567
3D
1gdtA03 - 82.3
8934
7545
EC
- - 42.8
124717
7217
EC
3D
3k2aA00 - 81.2
124211
7189
EC
3D
5iybJ00 - 94.4
124814
7039
EC
3D
1irzA00 - 95.6
125071
5973
3D
2r0qC02 - 97.8
21321
5785 - - 25.3
124216
5602
EC
3D
3rkqA00 - 82.5
124278
5170 - - 72.1
124604
4931
3D
1gv2A01 - 89.4
20011
4668 - - 42.0
124085
4312
EC
3D
3a01B00 - 73.2
6781
3931 - - 5.4
124998
3921 - - 98.0
124210
3687 - - 99.2
124168
3412
EC
- - 88.9
124591
3101
EC
- - 83.1
123467
3098
EC
3D
1b8iA00 - 84.6
124590
3053
3D
1ocpA00 - 97.1
77569
3025 - - 0.0
74999
2753 - - 6.8
124516
2725 - - 56.3
124184
2664 - - 88.7
123516
2639 - - 5.8
124199
2596
EC
3D
2ld5A00 - 92.3
124791
2547
EC
3D
1guuA00 - 88.4
124223
2432
EC
3D
2l7fP00 - 84.2
124798
2381
3D
2da2A01 - 90.8
3283
2360
EC
- - 36.5
123639
2330
EC
3D
1u8bA02 - 69.9
124794
2077
EC
3D
2yusA01 - 85.6
24935
2012 - - 0.0
124246
2008
3D
3zqcA02 - 94.9
39438
2008 - - 25.0
124848
1992
EC
3D
1ba5A00 - 92.7
124221
1982
EC
- - 85.0
78891
1981 - - 27.8
123211
1960
EC
- - 100.0
124236
1947 - - 85.0
123651
1933 - - 86.3
124638
1919 - - 74.1
124224
1900 - - 94.4
124115
1847
EC
3D
2djnA01 - 81.1
124229
1842 - - 89.5
125006
1783
EC
3D
1ofcX02 - 99.4
83153
1771 - - 51.6
124330
1770
EC
3D
1jggA00 - 85.7
124737
1768 - - 96.2
124648
1767 - - 4.5
31469
1760 - - 30.2
123888
1651 - - 89.2
125233
1638
3D
3hm5A00 - 82.2
124660
1622 - - 84.7
124704
1617
3D
4bkxA02 - 97.8
123901
1591
EC
3D
5hodA00 - 86.8
1506
I
1553
EC
- - 32.0
124188
1516
EC
- - 91.4
124903
1479
EC
- - 100.0
124017
1466
3D
1s7eA02 - 83.3
3230
1456 - - 88.8
13566
1441 - - 72.8
124131
1440 - - 86.7
124387
1426
3D
2da3A01 - 84.5
124093
1407
EC
- - 93.9
123559
1356
EC
3D
1umqA00 - 58.5
124109
1311
EC
3D
1du6A00 - 75.7
124616
1271
3D
1wh5A00 - 97.3
124269
1260 - - 87.5
124628
1256 - - 84.7
98027
1216 - - 49.6
55155
1209
3D
1vi0A01 - 83.5
124609
1180 - - 95.7
123150
1145 - - 63.8
124140
1133
3D
1gv2A02 - 91.5
123928
ATMYB4
1114 - - 80.5
36974
1090 - - 14.0
123976
1069
EC
- - 91.4
124579
1067
3D
1du0A00 - 94.9
123911
1052
EC
3D
3cmyA00 - 77.1
123684
1036
EC
3D
1bw5A00 - 65.5
124601
999
3D
2cjjA00 - 99.1
124106
997
EC
- - 95.7
123896
975 - - 86.3
124740
969
EC
3D
2cqxA01 - 98.9
25321
929 - - 44.8
124073
924 - - 96.5
124112
ATMYB4
910 - - 92.4
124620
895
EC
3D
2vi6A00 - 91.4
123781
811
EC
3D
2cueA01 - 73.2
28533
802 - - 18.4
124569
782
3D
1ftzA00 - 92.4
123417
756 - - 87.0
124001
733
EC
3D
2dmqA01 - 76.1
123898
731
EC
- - 85.1
123502
693
EC
- - 81.1
123889
689 - - 92.3
3232
676 - - 0.0
123506
667 - - 91.0
124718
658 - - 87.8
123384
648 - - 57.8
125064
634 - - 92.7
123894
615 - - 92.5
123262
606 - - 87.7
101367
596
EC
3D
1ojlA03 - 69.2
124024
594 - - 88.9
125112
589
3D
2cufA01 - 95.9
123470
570
EC
3D
2l9rA00 - 85.8
124815
566
3D
4w1uA01 - 79.2
123878
547
EC
- - 85.8
123051
539
EC
3D
1ofcX04 - 86.7
123797
532 - - 81.1
124920
510
3D
1rr7A02 - 99.4
123475
485
3D
3d1nL02 - 66.9
124810
480 - - 93.2
794
466
EC
- - 89.3
123316
463
EC
- - 74.0
124641
461 - - 94.5
123422
453
EC
- - 80.2
123595
449
EC
- - 75.8
124632
RE
449
EC
- - 91.6
2229
447
EC
- - 92.5
124029
445 - - 77.6
123319
444
EC
3D
2m34A00 - 72.7
12348
444 - - 63.1
124446
442 - - 46.2
124057
432 - - 95.5
124827
429 - - 95.7
124067
429
3D
3narA00 - 88.8
124623
428
3D
2dmpA01 - 92.3
124618
418
3D
2k40A00 - 93.8
124652
408 - - 87.0
123411
407
EC
- - 78.6
123615
405 - - 77.6
25598
400 - - 24.2
123947
371 - - 86.0
125023
367
3D
2da4A01 - 97.7
123301
366
3D
1ic8A02 - 65.2
7744
364 - - 65.8
24550
348 - - 76.9
124600
344
3D
1akhB00 - 58.1
98033
344
EC
- - 13.6
125085
342 - - 77.9
123134
341
3D
2mw8A00 - 62.1
124322
333
3D
3nauA00 - 84.3
123631
316 - - 48.0
123114
306
EC
- - 92.7
123137
304
EC
- - 79.0
20018
297 - - 20.2
5893
288
EC
- - 40.4
124012
283
3D
1uhsA01 - 84.3
1551
275 - - 65.3
124602
259 - - 77.0
7311
258 - - 44.9
35415
256 - - 0.0
123988
251
3D
1xc5A01 - 38.2
48695
251 - - 25.4
2290
232
EC
3D
4uusA00 - 79.7
124677
231
3D
2cu7A01 - 67.3
124685
231
EC
- - 89.6
124937
224
3D
1ug2A01 - 85.9
124964
224 - - 93.6
102925
222 - - 87.7
124577
222 - - 91.0
36647
215 - - 65.2
123695
215
3D
2e1oA01 - 82.6
49038
213 - - 31.1
123661
212
EC
- - 87.5
124930
201
EC
- - 86.5
123588
198 - - 54.1
124934
193 - - 72.1
124551
192 - - 82.0
63295
189 - - 69.6
123536
189
3D
2h1kA00 - 80.1
48774
181
3D
1hcrA00 - 16.6
119535
180 - - 33.3
35214
180 - - 54.0
124666
174 - - 95.2
124694
172 - - 94.5
124133
170 - - 83.1
92003
167
EC
- - 73.6
124327
165
EC
- - 66.2
123630
164 - - 34.3
75839
163 - - 47.1
125134
154
3D
1tc3C00 - 99.3
123091
154 - - 47.4
2963
150 - - 49.8
125154
149 - - 97.0
29109
149 - - 0.0
71892
144 - - 0.0
123395
143 - - 73.3
124555
Eurofung
142
EC
- - 91.5
123378
140 - - 48.1
5272
139 - - 48.1
20439
137 - - 73.9
76757
137 - - 14.9
124575
134 - - 69.8
17071
133 - - 35.5
77641
129 - - 70.6
123039
127 - - 76.5
125083
125 - - 92.3
124136
125 - - 48.5
31459
125 - - 19.4
124534
124 - - 67.9
124277
123 - - 41.1
14401
121 - - 25.6
123613
119 - - 30.1
124647
Mouse
119 - - 54.3
35789
116 - - 37.1
123759
114 - - 45.4
85947
111 - - 30.3
123712
109
3D
2e19A01 - 8.0
124528
106 - - 73.8
124014
103 - - 71.5
124411
98 - - 32.8
123194
98 - - 52.6
14393
98 - - 30.9
53966
96 - - 21.5
94752
96 - - 15.1
124427
93 - - 78.9
79012
92 - - 53.5
124218
89 - - 87.1
123545
88 - - 67.5
123825
87 - - 48.6
75853
86 - - 13.4
123915
84 - - 59.1
15222
84
3D
1q1vA00 - 39.8
25374
83 - - 43.8
123069
81 - - 23.0
123830
81 - - 0.0
124959
78 - - 60.5
1515
78
3D
3ukgA02 - 62.2
103492
76 - - 59.0
82976
74 - - 63.8
58948
73 - - 25.4
123665
70 - - 63.0
101466
70 - - 71.3
123641
69 - - 56.6
10739
69 - - 17.8
125017
69 - - 5.7
23096
68 - - 6.2
123922
67 - - 65.4
125039
66 - - 27.0
79419
66 - - 58.7
123007
63 - - 30.3
123537
62 - - 59.6
28107
62 - - 26.1
23095
61 - - 33.9
8480
61 - - 1.6
123907
60 - - 49.0
123503
60 - - 38.0
12894
59 - - 76.7
125081
58
3D
1ignA02 - 73.2
67788
58 - - 2.5
94941
57 - - 74.2
23854
54
EC
3D
3gbgA03 - 7.6
25308
54 - - 41.3
123054
54 - - 44.7
78626
54 - - 0.0
123859
53
EC
- - 40.4
23082
53 - - 4.3
123629
53 - - 46.3
5271
52 - - 65.6
105929
52 - - 21.0
73665
51 - - 2.3
10131
50 - - 54.1
43948
50 - - 18.3
124626
50 - - 61.1
103467
49 - - 0.0
48863
49 - - 0.0
869
49 - - 11.4
124480
49 - - 6.8
105984
49 - - 0.0
123923
48 - - 16.9
124804
48 - - 91.9
12911
47 - - 18.6
11767
45 - - 60.9
123090
44 - - 34.4
123826
44 - - 45.2
100983
44
EC
- - 13.5
55016
43 - - 31.6
124524
42
EC
- - 58.7
16072
42 - - 19.9
2876
40 - - 5.4
125103
40 - - 68.8
123778
39 - - 58.3
123140
39 - - 44.1
123707
39 - - 46.7
27154
39 - - 14.2
18546
39 - - 29.4
45709
39 - - 19.5
100988
39
EC
- - 15.7
23098
38 - - 8.1
53868
38
EC
- - 9.7
18916
38 - - 0.0
23093
37 - - 0.0
28229
37
EC
- - 24.6
18939
36 - - 0.0
39444
36 - - 0.0
94795
36 - - 0.0
124139
35 - - 56.1
23090
34 - - 10.3
123979
34 - - 70.7
21305
34 - - 69.1
1366
34
3D
2y9yA04 - 3.5
124739
33 - - 97.1
28105
32
3D
1hlvA02 - 14.3
124155
32 - - 61.6
123008
32 - - 42.8
124543
32 - - 55.2
20003
31 - - 24.8
39616
31 - - 24.2
19996
30
3D
1mh3A03 - 35.5
125052
30
3D
1iufA01 - 95.1
123944
29 - - 24.3
17131
29 - - 11.2
123433
28 - - 37.3
125104
28 - - 32.1
94797
28 - - 2.9
124461
28 - - 59.3
8649
28 - - 6.4
21326
28
3D
2fq4A01 - 20.8
45686
28
3D
1hlvA01 - 23.8
1680
I
27 - - 0.0
44183
27 - - 0.0
103468
26 - - 8.0
123191
26 - - 27.2
123218
26 - - 48.6
28106
26 - - 9.1
159
25 - - 8.3
123044
25 - - 46.7
89007
25 - - 0.0
124649
24 - - 87.0
7386
24 - - 29.4
123101
23 - - 40.2
124673
23 - - 67.7
33226
22 - - 10.2
2766
22 - - 4.4
6965
20 - - 24.2
32271
20 - - 60.4
6945
20 - - 18.8
124588
20 - - 71.4
22082
20 - - 7.4
124348
20 - - 66.5
54221
20 - - 14.7
28134
19 - - 19.7
23141
19 - - 23.1
2252
19 - - 43.9
23100
19 - - 8.8
16346
18 - - 32.0
23642
18 - - 26.6
123732
18 - - 37.1
43944
18 - - 0.0
63380
18 - - 0.0
123269
18 - - 24.2
28098
17 - - 1.8
8171
16 - - 0.0
39448
16 - - 0.0
79676
16 - - 24.6
124503
16 - - 0.0
39449
16 - - 0.0
53785
16 - - 0.0
44153
AraC/XylS family
16 - - 0.0
124655
16
EC
- - 69.0
124988
14 - - 18.6
125073
14
3D
1rr7A01 - 81.3
77132
14 - - 58.1
63285
14 - - 21.0
7472
14 - - 7.4
35184
13
EC
- - 2.2
21473
13 - - 26.2
22446
13
EC
- - 26.9
123728
13 - - 0.0
75019
13
EC
- - 4.9
124391
12 - - 43.3
10133
12
3D
2ezhA00 - 11.2
124592
12
3D
2ltpA00 - 36.8
14402
12 - - 12.8
63282
11 - - 8.7
89315
11 - - 45.6
123257
11 - - 22.2
72441
11 - - 14.3
39439
11 - - 2.3
5526
11 - - 31.1
4032
11
3D
2ezkA00 - 14.0
39450
E
10 - - 6.0
124490
10 - - 54.4
82857
10 - - 0.0
440
10 - - 31.3
6251
10 - - 41.7
7927
10 - - 3.5
87641
10 - - 0.0
124872
10 - - 69.8
20264
10 - - 4.1
12890
9 - - 1.9
90780
9 - - 0.0
13645
9 - - 25.6
21317
9 - - 37.5
28971
9 - - 9.2
103465
9 - - 0.0
56962
9 - - 0.0
101042
8
EC
- - 29.8
10442
8 - - 34.9
92092
8
EC
- - 5.3
11140
8 - - 6.1
124289
8 - - 46.4
85329
8
EC
- - 5.6
2947
8 - - 0.0
85931
8
EC
- - 12.2
10748
8 - - 25.5
88469
8 - - 0.0
28780
8
EC
- - 13.7
116298
8 - - 30.6
123278
7 - - 54.8
86131
7 - - 11.9
38088
7 - - 0.0
104060
7
EC
- - 14.6
39426
7 - - 26.7
14099
7 - - 10.1
54250
6 - - 6.3
76381
6 - - 15.4
75837
6
3D
2ibdA01 - 2.3
124459
6 - - 52.0
123236
6
EC
- - 22.2
71877
6 - - 4.8
15285
6 - - 14.4
5386
5 - - 31.0
7892
5 - - 0.0
89570
5 - - 8.4
108359
5
EC
- - 0.0
91948
5 - - 31.6
98029
5
EC
- - 7.2
35192
5 - - 0.0
2875
5 - - 29.0
39457
5 - - 21.5
29897
5 - - 5.2
4130
5 - - 11.5
124962
5 - - 25.6
35201
5 - - 32.7
85950
5
EC
- - 0.0
1051
I
5
EC
- - 12.9
10206
5 - - 26.6
13896
5 - - 11.1
67149
5 - - 14.4
10347
4 - - 14.4
68540
4 - - 8.8
55076
4 - - 0.0
124680
4 - - 40.4
5068
4 - - 11.6
123299
4 - - 17.0
18900
4
EC
- - 17.7
67789
4 - - 8.9
14053
4 - - 14.1
123252
4 - - 27.6
53790
4 - - 0.0
66689
4 - - 16.0
91944
4
EC
- - 7.0
124301
4 - - 0.0
82782
4 - - 0.0
37414
4 - - 2.2
18391
3 - - 15.3
123866
3
3D
1iufA02 - 37.5
10102
3 - - 4.0
16075
3 - - 5.4
123784
3 - - 27.2
125036
3 - - 47.6
23426
3
EC
- - 15.7
13647
3
EC
- - 12.4
40137
3 - - 0.0
12909
3 - - 7.6
16093
3 - - 0.0
31080
3 - - 13.9
20141
3 - - 7.2
4691
3 - - 7.2
123764
3
EC
- - 39.4
53787
2 - - 8.4
28087
2 - - 10.6
36153
2 - - 16.5
11869
2 - - 18.1
124522
2 - - 0.0
21671
2 - - 0.0
124996
2 - - 48.0
5281
2 - - 8.0
89910
2 - - 2.8
12969
2 - - 0.0
6316
2 - - 1.6
18975
2 - - 5.3
34302
2 - - 8.5
7354
2 - - 0.0
124576
2 - - 7.8
12132
2 - - 0.0
124425
2 - - 24.9
123833
2 - - 32.6
6248
2 - - 11.7
13427
2 - - 11.8
125184
2 - - 18.8
124541
2 - - 34.5
124415
2 - - 39.1
13641
2 - - 9.6
10760
2 - - 1.8
21966
2 - - 3.6
100980
2 - -
123755
2
EC
- - 30.5
16954
2 - - 2.1
58578
2 - - 20.6
89000
2 - - 8.9
79522
2 - - 15.5
39432
2
EC
- - 2.3
2515
2 - - 4.8
25319
1 - - 0.0
95696
1 - - 0.0
85935
1 - - 0.0
53799
1 - - 0.0
17130
1 - - 0.0
75838
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71198
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124956
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85941
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60263
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27254
1 - - 0.0
36211
1 - -
24030
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16958
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35299
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71947
1 - -
115291
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31468
1 - - 0.0
9367
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96231
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124702
1 - - 0.0
43940
1
EC
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91476
1 - -
17875
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7531
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10927
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53811
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14553
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61518
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35199
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94764
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12139
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123307
1 - - 0.0
35200
1 - - 0.0
77312
1 - -
85422
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2682
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67790
1 - - 0.0
51284
1 - -
19998
1 - - 0.0
72222
1 - - 0.0
2123
1 - - 0.0
3164
1 - - 0.0
44414
1 - - 0.0