CATH Classification

Domain Context

CATH Clusters

Superfamily Aldolase class I
Functional Family Pentafunctional AROM polypeptide

Enzyme Information

1.1.1.25
Shikimate dehydrogenase.
based on mapping to UniProt B0XRM8
Shikimate + NADP(+) = 3-dehydroshikimate + NADPH.
-!- NAD(+) cannot replace NADP(+). -!- In higher organisms, this enzyme forms part of a multienzyme complex with EC 4.2.1.10.
4.2.3.4
3-dehydroquinate synthase.
based on mapping to UniProt B0XRM8
3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate = 3-dehydroquinate + phosphate.
-!- The hydrogen atoms on C-7 of the substrate are retained on C-2 of the products. -!- Formerly EC 4.6.1.3.
4.2.1.10
3-dehydroquinate dehydratase.
based on mapping to UniProt B0XRM8
3-dehydroquinate = 3-dehydroshikimate + H(2)O.
2.7.1.71
Shikimate kinase.
based on mapping to UniProt B0XRM8
ATP + shikimate = ADP + shikimate 3-phosphate.
2.5.1.19
3-phosphoshikimate 1-carboxyvinyltransferase.
based on mapping to UniProt B0XRM8
Phosphoenolpyruvate + 3-phosphoshikimate = phosphate + 5-O- (1-carboxyvinyl)-3-phosphoshikimate.

UniProtKB Entries (1)

B0XRM8
ARO1_ASPFC
Aspergillus fumigatus A1163
Pentafunctional AROM polypeptide

PDB Structure

PDB 5SWU
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Dehydroquinate dehydratase from A. fumigatus AroM
Light, S.H., Minasov, G., Anderson, W.F., Center for Structural Genomics of Infectious Diseases (CSGID)
To Be Published