CATH Classification

Domain Context

CATH Clusters

Superfamily P-loop containing nucleotide triphosphate hydrolases
Functional Family ATP-dependent RNA helicase RhlB

Enzyme Information

3.6.4.13
RNA helicase.
based on mapping to UniProt P09052
ATP + H(2)O = ADP + phosphate.
-!- RNA helicases utilize the energy from ATP hydrolysis to unwind RNA. -!- Some of them unwind RNA with a 3' to 5' polarity, other show 5' to 3' polarity. -!- Some helicases unwind DNA as well as RNA. -!- May be identical with EC 3.6.4.12 (DNA helicase).

UniProtKB Entries (1)

P09052
VASA1_DROME
Drosophila melanogaster
ATP-dependent RNA helicase vasa

PDB Structure

PDB 5NT7
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
The LOTUS domain is a conserved DEAD-box RNA helicase regulator essential for the recruitment of Vasa to the germ plasm and nuage.
Jeske, M., Muller, C.W., Ephrussi, A.
Genes Dev.